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ARN19689 

Cat. No.: HY-132882
Handling Instructions

ARN19689 is a potent, selective, orally active and non-covalent inhibitor of N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA), with an IC50 of 42 nM. ARN19689 is a promising pharmacological tool to be further investigated in the field of inflammatory conditions.

For research use only. We do not sell to patients.

ARN19689 Chemical Structure

ARN19689 Chemical Structure

CAS No. : 2320521-34-2

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Description

ARN19689 is a potent, selective, orally active and non-covalent inhibitor of N‑Acylethanolamine-Hydrolyzing Acid Amidase (NAAA), with an IC50 of 42 nM. ARN19689 is a promising pharmacological tool to be further investigated in the field of inflammatory conditions[1].

IC50 & Target

IC50: 42 nM (N‑Acylethanolamine-Hydrolyzing Acid Amidase)[1]

In Vitro

ARN19689 (30 μM) inhibits the activity of human FAAH and human acid ceramidase by 25 and 34%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ARN19689 exhibits high plasma concentrations following i.v. (3 mg/kg) and p.o. (10 mg/kg) administration, low volume of distribution and clearance, and good oral bioavailability in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.51

Formula

C₁₉H₂₇N₅O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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ARN19689
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