N-Acetyldopamine dimer-2
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.
For research use only. We do not sell to patients.
- CAS No.: 916888-49-8
- Formula: C20H20N2O6
- Molecular Weight:384.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.5 μM (copper-mediated LDL oxidation), 2.7 μM (AAPH-mediated LDL oxidation), 1.6 μM (SIN-1-mediated LDL oxidation)[1]
N-Acetyldopamine dimer-2 inhibits copper-mediated, 2,2’azobis(2-amidinopropane) hydrochloride (AAPH)-mediated, and 3-morpholinosydnonimine (SIN)-1-mediated LDL oxidation with IC50 values of 1.5, 2.7 and 1.6 μM, respectively[1]. N-Acetyldopamine dimer-2 (100 μM; 40 min) shows strong radical scavenging capacity[1]. N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently reduces the ROS level in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1]. N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently and slightly decreases the NO production and iNOS protein expression in LPS-stimulated RAW264.7 cells[1]. N-Acetyldopamine dimer-2 (0-400 μM; 2 h) decreases the mRNA levels of IL-6, TNF-α, and COX-2 and dose-dependently inhibits secretion of IL-6, and inhibits the LPS-induced NF-κB activation in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-stimulated RAW264.7 cell line
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Concentration:200 and 400 μM
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Incubation Time:2 hours
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Result:Slightly decreased iNOS protein expression in LPS-stimulated RAW264.7 cells.
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Cell Line:LPS-stimulated RAW264.7 cell line
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Concentration:200 and 400 μM
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Incubation Time:2 hours
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Result:Dose-dependently decreased the mRNA levels of IL-6, TNF-α and COX-2.
Chemical Information
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CAS No. 916888-49-8
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Molecular Weight 384.38
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Formula C20H20N2O6
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SMILES
OC(C=CC([C@H]1OC2=CC(/C=C/NC(C)=O)=CC=C2O[C@@H]1NC(C)=O)=C3)=C3O
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Initial Source
Cryptotympana sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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