2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-14

COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice.

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COX-2-IN-14

COX-2-IN-14 Chemical Structure

CAS No. : 2428387-48-6

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COX-2-IN-14 Related Antibodies

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Description

COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1].

IC50 & Target

COX-2

 

Cellular Effect
Cell Line Type Value Description References
J774.A1 CC50
< 100 μM
Compound: 2a
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 32503692]
L929 CC50
257.42 μM
Compound: 2a
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 32503692]
Molecular Weight

386.36

Formula

C18H18N4O6
CAS No.
SMILES

CCOC(C1=C(C=C(C([O-])=N1)C#N)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O.C[NH2+]C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-142428387-48-6COXCyclooxygenase2-pyridoneanti-inflammatoryCOXscyclooxygenaseL929 fibroblastsJ774A1 macrophagespyridinium saltInhibitorinhibitorinhibit

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