COX-2-IN-14
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice.
For research use only. We do not sell to patients.
- CAS No.: 2428387-48-6
- Formula: C18H18N4O6
- Molecular Weight:386.36
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
COX-2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | CC50 |
<100 μM
Compound: 2a
|
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32503692] |
| L929 | CC50 |
257.42 μM
Compound: 2a
|
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32503692] |
Chemical Information
-
CAS No. 2428387-48-6
-
Molecular Weight 386.36
-
Formula C18H18N4O6
-
SMILES
CCOC(C1=C(C=C(C([O-])=N1)C#N)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O.C[NH2+]C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-14 Related Classifications
HY-147692 Related Classifications
Powered by Bioz