2428387-48-6
Chemical Structure
COX-2-IN-14
- CAS No.: 2428387-48-6
- Formula:C18H18N4O6
- Molecular Weight:386.36
IUPAC Name: dimethylammonium 3-cyano-6-(ethoxycarbonyl)-5-(4-nitrobenzoyl)pyridin-2-olate
InChIKey: BPWODPJMZWXVOZ-UHFFFAOYSA-N
SMILES: CCOC(C1=C(C=C(C([O-])=N1)C#N)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O.C[NH2+]C
Biological Activity: COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1].
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COX-2-IN-14 | COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice. | |||||||||||||||||||||
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Keywords
