1. Immunology/Inflammation
    Apoptosis
  2. NO Synthase
    TNF Receptor
  3. DHU-Se1

DHU-Se1 

Cat. No.: HY-151188
Handling Instructions

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1.

For research use only. We do not sell to patients.

DHU-Se1 Chemical Structure

DHU-Se1 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1[1].

IC50 & Target

Selenium, iNOS, TNF-α[1]

In Vitro

DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells[1].
DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors[1].
DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: RAW cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Displayed low biological toxicity with a survival rate larger than 80%.

RT-PCR[1]

Cell Line: RAW cells (co-treated with 100 ng/mL LPS)
Concentration: 20 μM
Incubation Time: 24 h
Result: Reduced the expression of TNF-α and iNOS significantly.

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages (co-treated with 100 ng/mL LPS)
Concentration: 20 μM
Incubation Time: 24 h
Result: Significantly decreased the expression level of iNOS, indicating that M0 to M1 polarization was blocked.
Released the reactive selenium compound.
Molecular Weight

468.47

Formula

C23H23N3OSSe

SMILES

CN(C1=CC=C2C(SC3=C(N2C([Se]C4=CC=CC=C4)=O)C=CC(N(C)C)=C3)=C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
DHU-Se1
Cat. No.:
HY-151188
Quantity:
MCE Japan Authorized Agent: