DHU-Se1
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1.
For research use only. We do not sell to patients.
- Formula: C23H23N3OSSe
- Molecular Weight:468.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Selenium, iNOS, TNF-α[1]
DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells[1].
DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors[1].
DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW cells
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Concentration:50 μM
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Incubation Time:24 h
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Result:Displayed low biological toxicity with a survival rate larger than 80%.
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Cell Line:RAW cells (co-treated with 100 ng/mL LPS)
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Concentration:20 μM
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Incubation Time:24 h
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Result:Reduced the expression of TNF-α and iNOS significantly.
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Cell Line:RAW 264.7 macrophages (co-treated with 100 ng/mL LPS)
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Concentration:20 μM
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Incubation Time:24 h
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Result:Significantly decreased the expression level of iNOS, indicating that M0 to M1 polarization was blocked.
Released the reactive selenium compound.
Chemical Information
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Molecular Weight 468.47
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Formula C23H23N3OSSe
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SMILES
CN(C1=CC=C2C(SC3=C(N2C([Se]C4=CC=CC=C4)=O)C=CC(N(C)C)=C3)=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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