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TXNIP-IN-1 

Cat. No.: HY-115688
Handling Instructions

TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.

For research use only. We do not sell to patients.

TXNIP-IN-1 Chemical Structure

TXNIP-IN-1 Chemical Structure

CAS No. : 1268955-50-5

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Description

TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease[1].

IC50 & Target

TXNIP-TRX complex[1]

In Vitro

TXNIP-IN-1 bocks high glucose (HG induced) TXNIP-TRX complex formation[1].
TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF in monocytes[1].
TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression in THP1 cells[1].
TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages[1].
TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels in MIN6 cells[1].
TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in human pancreas 1.1B4 beta cells[1].
TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose[1].
TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets[1].

Molecular Weight

248.23

Formula

C₁₂H₁₂N₂O₄

CAS No.

1268955-50-5

SMILES

O=C(O)C(C(C)C)N(C1=O)C(C2=C1C=CN=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TXNIP-IN-1Othersthioredoxin-interactingproteinthioredoxinTXNIPTRXdiabetesInhibitorinhibitorinhibit

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