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Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derivatized from the nile blue fluorophore. Trx-red is used for selectively imaging thioredoxin (Trx) in live cells and in vivo (λex=615 nm, λem=661 nm) .
Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes .
Trilexium (TRX-E-009-1) is a third-generation of benzopyran structurally related to TRX-E-002-1 (HY-114250). Trilexium increases p21 protein expression and induces apoptosis. Trilexium depolymerizes microtubules. Trilexium shows broad anti-cancer activity .
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .
BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye. BODIPY TR-X can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, red fluorescent light. (λex=545 nm, λem=560 nm) .
(S)-TXNIP-IN-1 is the less active S-enantiomer of TXNIP-IN-1 (HY-115688). TXNIP-IN-1 is a TXNIP-TRX complex inhibitor which can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease
TXNIP-IN-1 is TXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complex inhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease .
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .
BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λex=544 nm, λem=570 nm) .
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) .
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .
Trx-red (NBL-SS perchlorate) is a red-emitting fluorescent probe derivatized from the nile blue fluorophore. Trx-red is used for selectively imaging thioredoxin (Trx) in live cells and in vivo (λex=615 nm, λem=661 nm) .
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .
FM-red (PSH-red) is a red-emitting and environment-sensitive probe for selectively detecting and labeling protein thiols. FM-red can be used to image protein sulfhydryl groups in live cells and in vivo. FM-red also could be used to measure of the redox states of thioredoxin (Trx) .
BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye. BODIPY TR-X can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, red fluorescent light. (λex=545 nm, λem=560 nm) .
BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λex=544 nm, λem=570 nm) .
Thioredoxin/TXN Protein participates in diverse redox reactions, using its active center dithiol for reversible oxidation and disulfide bond formation. It catalyzes crucial dithiol-disulfide exchanges and plays a pivotal role in S-nitrosylation of cysteine residues, responding to intracellular nitric oxide. Thioredoxin regulates caspase-3 activity by nitrosylating CASP3's active site cysteine. It also influences FOS/JUN AP-1 DNA binding and augments interleukin-2 receptor expression, showcasing its multifaceted cellular role beyond redox regulation. Thioredoxin/TXN Protein, Human is the recombinant human-derived Thioredoxin/TXN protein, expressed by E. coli, with tag free. The total length of Thioredoxin/TXN Protein, Human is 105 a.a., with molecular weight of ~14 kDa.
Thioredoxin/TRX Protein engages in diverse redox reactions, utilizing its active dithiol center for reversible oxidation and disulfide formation. It catalyzes essential dithiol-disulfide exchanges and plays a crucial role in S-nitrosylation of cysteine residues, responding to intracellular nitric oxide. Thioredoxin inhibits CASP3 activity by nitrosylating its active site cysteine. It also regulates FOS/JUN AP-1 DNA binding activity and influences interleukin-2 receptor expression, showcasing its multifaceted cellular role beyond redox regulation. Thioredoxin/TRX Protein, Mouse (N-His) is the recombinant mouse-derived Thioredoxin/TRX protein, expressed by E. coli, with N-6*His labeled tag. The total length of Thioredoxin/TRX Protein, Mouse (N-His) is 105 a.a., with molecular weight of ~15 kDa.
Thioredoxin/TXN Protein, E.coli (His) is a hydrogen carrier protein and exists widely in organism. Thioredoxin suppression disbalances insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition.
Thioredoxin/TXN protein participates in multiple redox reactions, utilizing its active center dithiol for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide. Thioredoxin/TXN Protein, Human (Solution) is the recombinant human-derived Thioredoxin/TXN protein, expressed by E. coli , with tag free. The total length of Thioredoxin/TXN Protein, Human (Solution) is 105 a.a., with molecular weight of ~14 kDa.
Thioredoxin/TRX proteins participate in multiple redox reactions, utilizing their reactive dithiol centers for reversible oxidation and disulfide bond formation. It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide. Thioredoxin/TRX Protein, Mouse is the recombinant mouse-derived Thioredoxin/TRX protein, expressed by E. coli , with tag free. The total length of Thioredoxin/TRX Protein, Mouse is 105 a.a., with molecular weight of ~15 kDa.
As a monomer, the TXN2 protein is critical for maintaining mitochondrial reactive oxygen species (ROS) homeostasis, regulating apoptosis, and ensuring cell viability. Its unique dithiol reducing activity fine-tunes cellular redox balance, making a significant contribution to overall cellular health. TXN2 Protein, Human (His) is the recombinant human-derived TXN2 protein, expressed by E. coli , with tag free. The total length of TXN2 Protein, Human (His) is 107 a.a., with molecular weight of ~13 kDa.
Thioredoxin-1/TRXA Protein participates in diverse redox reactions, facilitating reversible oxidation of its active center dithiol to form a disulfide bond and catalyzing critical dithiol-disulfide exchanges. Operating as a monomer, Thioredoxin-1 exhibits versatility in redox functions and interacts with bacteriophage T3 DNA polymerase, suggesting broader involvement in molecular processes beyond its primary redox activities. Thioredoxin-1/TRXA Protein, E.coli (His) is the recombinant E. coli-derived Thioredoxin-1/TRXA protein, expressed by E. coli , with N-His labeled tag. The total length of Thioredoxin-1/TRXA Protein, E.coli (His) is 108 a.a., with molecular weight of ~15.7 kDa.
ABCB5, N-Trx Protein, Human is a plasma membrane-spanning protein that in humans is encoded by the ABCB5 gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally expressed in physiological skin and human malignant melanoma.
CD72 Protein plays a key role in orchestrating B-cell proliferation and differentiation, forming homodimers with disulfide linkages and interacting with CD5. It engages in tyrosine phosphorylation interactions with PTPN6/SHP-1, indicating its modulation of cellular responses through phosphorylation-based regulatory mechanisms. This underscores the multifaceted role of CD72 in the dynamic landscape of B-cell function and signaling. CD72 Protein, Human (N-Trx-6His) is the recombinant human-derived CD72 protein, expressed by E. coli , with N-Trx, N-His labeled tag. The total length of CD72 Protein, Human (N-Trx-6His) is 110 a.a., with molecular weight of 26-35 kDa.
CD20/MS4A1 Protein, a B-lymphocyte membrane protein, crucially regulates cellular calcium influx, essential for B-lymphocyte development, differentiation, and activation. As part of the store-operated calcium (SOC) channel, it promotes calcium influx upon B-cell receptor/BCR activation. CD20/MS4A1 forms homotetramers, contributing to its structural organization in calcium signaling. Interacting with both heavy and light chains of cell surface IgM, the antigen-binding components of the BCR, emphasizes its involvement in the B-cell receptor complex, underscoring significance in B-cell activation and immune responses. CD20/MS4A1 Protein, Human (Trx-His) is the recombinant human-derived CD20/MS4A1 protein, expressed by E. coli, with N-Trx, N-6*His labeled tag. The total length of CD20/MS4A1 Protein, Human (Trx-His) is 48 a.a., with molecular weight of approximately 20.91 kDa.
PPIC protein is a peptidyl-prolyl cis-trans isomerase (PPIase) that actively catalyzes the cis-trans isomerization of prolyl imide peptide bonds, which is a key step in protein folding. Its role in promoting conformational changes ensures correct folding and maturation of proteins, contributing to cellular proteostasis. PPIC Protein, Human (Trx-His) is the recombinant human-derived PPIC protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of PPIC Protein, Human (Trx-His) is 152 a.a., with molecular weight of ~34.0 kDa.
SOCS3 is a member of the SOCS family that operates in a negative feedback loop to regulate cytokine signaling, particularly in the JAK/STAT pathway. It inhibits cytokine signaling by binding to receptors such as IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors. SOCS3 Protein, Human (His-Trx) is the recombinant human-derived SOCS3 protein, expressed by E. coli , with N-Trx, N-His labeled tag. The total length of SOCS3 Protein, Human (His-Trx) is 225 a.a., with molecular weight of ~46 kDa.
The HAO1 protein is a (S)-2-hydroxyacid oxidase with broad substrate specificity that facilitates glycolate oxidation. This activity produces glyoxylic acid, a key precursor for glycine synthesis. HAO1 Protein, Human (Trx-His) is the recombinant human-derived HAO1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of HAO1 Protein, Human (Trx-His) is 370 a.a., with molecular weight of ~56.0 kDa.
ACAT2, Human (Trx-His) is the major ACAT enzyme in human hepatocytes. ACAT2, Human is an important regulator of susceptibility to the development of atherosclerosis.
Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.
CD20/MS4A1 Protein, a B-lymphocyte membrane protein, crucially regulates cellular calcium influx, essential for B-lymphocyte development, differentiation, and activation. As part of the store-operated calcium (SOC) channel, it promotes calcium influx upon B-cell receptor/BCR activation. CD20/MS4A1 forms homotetramers, contributing to its structural organization in calcium signaling. Interacting with both heavy and light chains of cell surface IgM, the antigen-binding components of the BCR, emphasizes its involvement in the B-cell receptor complex, underscoring significance in B-cell activation and immune responses. CD20 Protein, Human (Trx) is the recombinant human-derived CD20 protein, expressed by E. coli, with N-Trx labeled tag. The total length of CD20 Protein, Human (Trx) is 48 a.a., with molecular weight of 28.2 kDa.
The CHRNA1 Protein undergoes a substantial conformational shift upon acetylcholine binding, influencing all subunits and leading to the activation of an ion-conducting channel. Yet, the acetylcholine receptor alpha subunit of CHRNA1 can be non-functional in certain cases, underscoring the need to comprehend the factors governing its functionality and integration into fully operational acetylcholine-gated cation-selective channels. CHRNA1 Protein, Human (His-Trx) is the recombinant human-derived CHRNA1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of CHRNA1 Protein, Human (His-Trx) is 235 a.a., with molecular weight of ~44.1 kDa.
Trx Tag Antibody (YA888) is an unconjugated, mouse-derived, anti-Trx Tag (YA888) monoclonal antibody. Trx Tag Antibody (YA888) can be used for: WB expriments in species-independent background without labeling.
Thioredoxin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 12 kDa, targeting to Thioredoxin. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.
DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB−MMAE and DBCO-TRX−MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) .
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