Serpin B6 Protein, Human (Trx-His)

Serpin B6 protein acts as a potential modulator of serine proteases in the brain or blood. It inhibits cathepsin G, kallikrein 8, and thrombin, suggesting a role in protease regulation. Serpin B6 Protein, Human (Trx-His) is the recombinant human-derived Serpin B6 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag. The total length of Serpin B6 Protein, Human (Trx-His) is 376 a.a., with molecular weight of 58-60 kDa.

The Serpin B6 protein emerges as a potential regulator, potentially playing a role in the modulation of serine proteinases found in the brain or extravasated from the blood. It functions as an inhibitor of cathepsin G, kallikrein-8, and thrombin, indicating its involvement in the regulation of these proteases. Notably, Serpin B6 may play a crucial role in the inner ear, contributing to the protection against the leakage of lysosomal content during stress. Loss of this protective function is implicated in cell death and sensorineural hearing loss, highlighting the significance of Serpin B6 in maintaining inner ear homeostasis. Additionally, the protein forms a complex with the monomeric form of beta-tryptase, further expanding its potential interactions and roles in cellular processes.

Human

E. coli

N-Trx;N-6*His

P35237 (M1-P376)

5269  [NCBI]

MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRVANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP

58-60 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.