ACAT2 Protein, Human (Trx-His)
ACAT2, Human (Trx-His) is the major ACAT enzyme in human hepatocytes. ACAT2, Human is an important regulator of susceptibility to the development of atherosclerosis.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
ACAT2, Human (Trx-His) is the major ACAT enzyme in human hepatocytes. ACAT2, Human is an important regulator of susceptibility to the development of atherosclerosis.
Background
ACAT2 is the major ACAT enzyme in human hepatocytes. Currently, two ACAT isozymes, ACAT1 and ACAT2, have been identified in humans and in animals. ACAT2 expression predominantly in the liver and intestine. ACAT2 is the major isoenzyme in monkey and mouse hepatocytes. ACAT1 is the major isoform in human hepatocytes. ACAT2 is identified as an important regulator of susceptibility to the development of atherosclerosis. Studies in mouse models of atherosclerosis showed reduced amounts of atherosclerosis when ACAT2 was deficient[1][2].
Technical Parameters
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Species Human
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Source E. coli
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Tag N-Trx;N-6*His
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Accession
Q9BWD1 (M1-E397)
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Molecular Construction
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N-term
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Trx-6*His
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ACAT2 (M1-E397)
Accession # Q9BWD1 -
C-term
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Protein Length
Full Length
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Synonyms
ACAT2; Acetoacetyl Coenzyme A Thiolase; Acetyl-CoA Acetyltransferase 2; Acetyl-Coenzyme A Acetyltransferase 2 (Acetoacetyl Coenzyme A Thiolase); Acetyl-CoA Acetyltransferase, Cytosolic; Acetyl-Coenzyme A Acetyltransferase 2; Acetyl-CoA Transferase-Like Pr
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AA Sequence
MNAGSDPVVIVSAARTIIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGHVLAAGCGQNPVRQASVGAGIPYSVPAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAGGMENMSKAPHLAYLRTGVKIGEMPLTDSILCDGLTDAFHNCHMGITAENVAKKWQVSREDQDKVAVLSQNRTENAQKAGHFDKEIVPVLVSTRKGLIEVKTDEFPRHGSNIEAMSKLKPYFLTDGTGTVTPANASGINDGAAAVVLMKKSEADKRGLTPLARIVSWSQVGVEPSIMGIGPIPAIKQAVTKAGWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAIALGHPLGASGCRILVTLLHTLERMGRSRGVAALCIGGGMGIAMCVQRE
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Predicted Molecular Mass
59.1 kDa
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Molecular Weight
Approximately 60 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Parini P, et, al. ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation. 2004 Oct 5;110(14):2017-23. [Content Brief]
[2]. Sakashita N, et, al. Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies. Lab Invest. 2003 Nov;83(11):1569-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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