COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC50 value of 1.14 nM. COX-2/PI3K-IN-1 is a selective COX-2 inhibitor with Ki value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.
For research use only. We do not sell to patients.
- Formula: C19H14ClN5S2
- Molecular Weight:411.93
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PI3K 1.14 nM (IC50) |
COX-2 3.24 nM (Ki) |
COX-2/PI3K-IN-1 (compound 5d) (50-500 µg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells[1].
COX-2/PI3K-IN-1 (compound 5d) (10-150 µg/mL) has antioxidant properties with H2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition(IC50=3.98 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Breast cancer (MCF-7) cells and normal breast epithelial (MCF-10A) cells
-
Concentration:50–500 µg/mL
-
Incubation Time:72 hours
-
Result:Caused 40 % cell death at 0.75 μM in MCF-7 cells.
Chemical Information
-
Molecular Weight 411.93
-
Formula C19H14ClN5S2
-
SMILES
S=C(/N=C1C(N(C2=CC=CC=C2Cl)C3=C\1C=CC=C3)=S)NCN4C=CN=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2/PI3K-IN-1 Related Classifications
HY-147911 Related Classifications
Powered by Bioz