1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Yangambin

Yangambin 

Cat. No.: HY-N4267
Handling Instructions

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM.

For research use only. We do not sell to patients.

Yangambin Chemical Structure

Yangambin Chemical Structure

CAS No. : 13060-14-5

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Description

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC50 of 33.8 μM and for anti-inflammatory activity with an IC50 of 37.4 μM[2].

IC50 & Target[1]

Ca2+

 

Molecular Weight

446.49

Formula

C₂₄H₃₀O₈

CAS No.

13060-14-5

SMILES

COC1=C(OC)C(OC)=CC([[email protected]]2OC[[email protected]]3([H])[[email protected]@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[[email protected]@]32[H])=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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