2. Anti-infection Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Flavivirus
  4. ZIKV-IN-6

ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC50＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis.

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ZIKV-IN-6

ZIKV-IN-6 Chemical Structure

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ZIKV-IN-6 Related Antibodies

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Description

ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC50＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis[1].

IC50 & Target

Zika virus (ZIKV)[1]
Cellular Effect
Cell Line Type Value Description References
A549 CC50
> 50 μM
Compound: 22
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37421888]
JEG-3 CC50
54.7 μM
Compound: 22
Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37421888]
SNB-19 CC50
66.1 μM
Compound: 22
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37421888]
Vero CC50
65.4 μM
Compound: 22
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 37421888]
Molecular Weight

463.52

Formula

C27H29NO6
SMILES

O=C1C2=C(C(O)=C(N3CCC(C4=CC=CC=C4)CC3)C=C2O)C(C5=C1C[C@@](C)(O)[C@@](C)(O)C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZIKV-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZIKV-IN-6DNA/RNA SynthesisFlavivirusInhibitorinhibitorinhibit

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