ZIKV-IN-6
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC50>50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis.
For research use only. We do not sell to patients.
- Formula: C27H29NO6
- Molecular Weight:463.52
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Zika virus (ZIKV)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>50 μM
Compound: 22
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
| JEG-3 | CC50 |
54.7 μM
Compound: 22
|
Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human JEG-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
| SNB-19 | CC50 |
66.1 μM
Compound: 22
|
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
| Vero | CC50 |
65.4 μM
Compound: 22
|
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 37421888] |
Chemical Information
-
Molecular Weight 463.52
-
Formula C27H29NO6
-
SMILES
O=C1C2=C(C(O)=C(N3CCC(C4=CC=CC=C4)CC3)C=C2O)C(C5=C1C[C@@](C)(O)[C@@](C)(O)C5)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)