1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK

CA-4948 

Cat. No.: HY-109585 Purity: 98.44%
Handling Instructions

CA-4948 is a selective and potent IRAK4 inhibitor.

For research use only. We do not sell to patients.

CA-4948 Chemical Structure

CA-4948 Chemical Structure

CAS No. : 1801343-74-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 202 In-stock
Estimated Time of Arrival: December 31
2 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CA-4948 is a selective and potent IRAK4 inhibitor.

IC50 & Target

IRAK4[1]

In Vivo

CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 31 mg/mL (74.27 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3957 mL 11.9783 mL 23.9567 mL
5 mM 0.4791 mL 2.3957 mL 4.7913 mL
10 mM 0.2396 mL 1.1978 mL 2.3957 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

417.42

Formula

C₂₁H₁₉N₇O₃

CAS No.

1801343-74-7

SMILES

O=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CA-4948
Cat. No.:
HY-109585
Quantity:

CA-4948

Cat. No.: HY-109585