2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) SARS-CoV
  4. SMU-CX1

SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5.

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SMU-CX1

SMU-CX1 Chemical Structure

CAS No. : 10371-86-5

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Based on 1 publication(s) in Google Scholar

SMU-CX1 Related Antibodies

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Description

SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5[1].

Cellular Effect
Cell Line Type Value Description References
A549 CC50
5.33 μM
Compound: NSC69187; SMU-CX
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38387691]
BEAS-2B CC50
5.33 μM
Compound: NSC69187; SMU-CX
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38387691]
HEK-293T CC50
5.33 μM
Compound: NSC69187; SMU-CX
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38387691]
KB ED50
8.7 μg/mL
Compound: 9-methoxy ellipticine
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
[PMID: 7130986]
MDCK CC50
5.33 μM
Compound: NSC69187; SMU-CX
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38387691]
R1 IC50
90 μM
Compound: 4
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
[PMID: 18412397]
Vero C1008 CC50
> 10 μM
Compound: NSC69187; SMU-CX
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability by CCK-8 assay
[PMID: 38387691]
Molecular Weight

276.33

Formula

C18H16N2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMU-CX1 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMU-CX110371-86-5Toll-like Receptor (TLR)SARS-CoVSARS coronavirusAnti-inflammatoryInfluenza A virusSARS-CoV-2Small moleculeInhibitorinhibitorinhibit

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