1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase
  3. Fluorometholone acetate

Fluorometholone acetate 

Cat. No.: HY-B1471 Purity: >98.0%
Handling Instructions

Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research.

For research use only. We do not sell to patients.

Fluorometholone acetate Chemical Structure

Fluorometholone acetate Chemical Structure

CAS No. : 3801-06-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[1][2][3].

IC50 & Target

IC50: 2.18 μM (human carbonic anhydrase (hCA)-I) and 17.5 μM (hCA-II)[2]
Ki: 1.044 μM (hCA-I) and 9.98 μM (hCA-II)[2]

In Vitro

For Fluorometholone acetate, a Ki value from Lineweaver-Burk plots is obtained as 1.044 μM (noncompetitive) for hCA-I and 9.98 μM (non-competitive) for hCA-II[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

418.50

Formula

C₂₄H₃₁FO₅

CAS No.

3801-06-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (597.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9474 mL 23.8949 mL
5 mM 0.4779 mL 2.3895 mL 4.7790 mL
10 mM 0.2389 mL 1.1947 mL 2.3895 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FluorometholoneCarbonic AnhydraseCarbonate dehydrataseCorneaanti-inflammatorycorticosteroidglucocorticoidhCA-IIhCA-IInhibitorinhibitorinhibit

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Product Name:
Fluorometholone acetate
Cat. No.:
HY-B1471
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