2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. FAAH Cannabinoid Receptor
  4. CB2R/FAAH modulator-2

CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.

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CB2R/FAAH modulator-2 Chemical Structure

CB2R/FAAH modulator-2 Chemical Structure

CAS No. : 2876918-68-0

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CB2R/FAAH modulator-2 Related Antibodies

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Description

CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

IC50 & Target[1]

CB1

152.9 nM (Ki)

CB2

10.8 nM (Ki)

In Vitro

CB2R/FAAH modulator-2 (compound 26)(10 μM) reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β and IL6 in unstimulated monocytes and macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB2R/FAAH modulator-2 Related Antibodies
Molecular Weight

367.52

Formula

C24H33NO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(OCC2CCCCC2)C=CC=C1)NC3(C4)C[C@H]5C[C@@H]4C[C@H](C5)C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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CB2R/FAAH modulator-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB2R/FAAH modulator-22876918-68-0FAAHCannabinoid ReceptorFatty acid amide hydrolaseCB2RCB1RcancerneurodegenerativeinflammatoryCOVID-19Inhibitorinhibitorinhibit

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