1. Immunology/Inflammation
  2. COX
  3. Enflicoxib

Enflicoxib (Synonyms: E 6087)

Cat. No.: HY-19384
Handling Instructions

Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models.

For research use only. We do not sell to patients.

Enflicoxib Chemical Structure

Enflicoxib Chemical Structure

CAS No. : 251442-94-1

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Description

Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models[1].

IC50 & Target[1]

COX-2

 

In Vivo

E-6132, one of Enflicoxib (E-6087) metabolites, also inhibits COX-2. After single oral administration of 5 mg/kg of E-6087 to rats, plasma concentrations of Enflicoxib at peak time are higher than those of E-6132, suggesting that activity is mainly due to Enflicoxib[1].
Enflicoxib (E-6087) is characterized by a long elimination half-life (20-35 h), a low plasma clearance (0.10-0.22 L/h/kg) and a relatively large volume of distribution (2-6 L/kg) in rats and dogs after single oral and intravenous doses. Enflicoxib and E-6132 (a pharmacologically active metabolite) show different pharmacokinetics. The higher percentage of Enflicoxib at early times suggests that Enflicoxib is the main compound responsible for in vivo activity, although E-6132 would contribute to the activity at later times[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Wistar rats (250 g)[1]
Dosage: 5 mg/kg
Administration: Administered by gastric gavage (10 mL/kg); a single oral dose
Result: Plasma concentrations of E-6087 at peak time are higher than those of E-6132.
Molecular Weight

405.34

Formula

C₁₆H₁₂F₅N₃O₂S

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Enflicoxib
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HY-19384
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