Angelicin  (Synonyms: Isopsoralen)

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

Angelicin (30-50 μM; 48 h) induced apoptosis in SH-SY5Y cells, causing downregulation of Bcl-2, Bcl-xL, and Mcl-1 protein expression, and activated the cleavage of caspase-9 and caspase-3, leading to apoptosis^[1].
Angelicin (28.95 μM; 48 h) inhibited viral replication in MHV-68-infected BHK21 cells, causing downregulation of viral proteins ORF45 and ORF65 expression, and reduced viral genome replication and RTA mRNA expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Angelicin (1, 5, 10 mg/kg; intraperitoneal injection; once, 1 hour before LPS induction) shows anti-inflammatory effects in the LPS-induced acute lung injury model in mice, reducing inflammatory cell infiltration and cytokine production by inhibiting the MAPK and NF-κB pathways^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

186.16

C₁₁H₆O₃

523-50-2

Solid

White to off-white

O=C1C=CC2=CC=C(OC=C3)C3=C2O1

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. Rahman MA, et al. Angelicin induces apoptosis through intrinsic caspase-dependent pathway in human SH-SY5Y neuroblastoma cells. Mol Cell Biochem. 2012 Oct;369(1-2):95-104.  [Content Brief]

  [2]. Cho HJ, et al. Antiviral activity of angelicin against gammaherpesviruses. Antiviral Res. 2013 Oct;100(1):75-83.  [Content Brief]

  [3]. Liu F, et al. Angelicin regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. J Surg Res. 2013 Nov;185(1):300-9.  [Content Brief]