Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity

  • Bioorg Med Chem Lett. 2003 Aug 18;13(16):2809-11. doi: 10.1016/s0960-894x(03)00529-8.
Paola Barraja  1 ,  Patrizia Diana ,  Antonino Lauria ,  Alessandra Montalbano ,  Anna Maria Almerico ,  Gaetano Dattolo ,  Girolamo Cirrincione ,  Giampietro Viola ,  Francesco Dall'Acqua
Affiliations
  • 1. Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi, Via Archirafi 32, 90123 Palermo, Italy.
PMID: 12873520 DOI: 10.1016/s0960-894x(03)00529-8
Abstract

A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.