1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. Izencitinib

Izencitinib (Synonyms: TD-1473; JNJ-8398)

Cat. No.: HY-109148
Handling Instructions

Izencitinib (TD-1473) is an orally active, non-selective and gut-restricted JAK inhibitor. Izencitinib (TD-1473) can be used in the study for ulcerative colitis.

For research use only. We do not sell to patients.

Izencitinib Chemical Structure

Izencitinib Chemical Structure

CAS No. : 2051918-33-1

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Description

Izencitinib (TD-1473) is an orally active, non-selective and gut-restricted JAK inhibitor. Izencitinib (TD-1473) can be used in the study for ulcerative colitis[1].

In Vitro

Izencitinib (TD-1473) inhibits cytokine-evoked STAT phosphorylation in human peripheral blood mononuclear cells (PBMCs) and in a human colonic epithelial cell line (pIC50 ≥ 6.7)[1].
Izencitinib (TD-1473) is a potent JAK1, JAK2, JAK3, and TYK2 inhibitor at the human JAK kinase domains (pKi values of 10.0, 10.0, 8.8, and 9.5, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Izencitinib (TD-1473, 1 mg/kg BID) preserves body weight and reduced occult blood scores in a mouse oxazolone colitis model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.50

Formula

C₂₂H₂₆N₈

CAS No.
SMILES

CC1=CC(NC2=CC3=C(C=CC=N3)C(N[[email protected]@H]4C[[email protected]@H](CC5)N(CCC#N)[[email protected]@H]5C4)=N2)=NN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IzencitinibTD-1473 JNJ-8398TD1473TD 1473JNJ8398JNJ 8398JNJ-8398JAKJanus kinaseUlcerativecolitiswelltoleratedInflammatoryboweldiseasesIBDInhibitorinhibitorinhibit

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Izencitinib
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HY-109148
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