2. Apoptosis
  3. TNF Receptor
  4. Placulumab

Placulumab  (Synonyms: ART621; CEP-37247; PN0621)

Cat. No.: HY-P99775

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Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis.

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Placulumab Chemical Structure

Placulumab Chemical Structure

CAS No. : 945781-29-3

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Placulumab Related Antibodies

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Description

Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1].

In Vitro

Placulumab (0.01-1000 µg/mL) has cytotoxicity to NS0 cells and peripheral blood mononuclear cells (PBMCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Placulumab Related Antibodies
In Vivo

Placulumab (0.3, 1, 3 and 10 mg/kg; i.p.; twice weekly for 8 weeks) has effective anti-arthritis properties in Tg197 transgenic mouse model[1].
Pharmacokinetic (PK) parameters of Placulumab in cynomolgus macaques[1]

Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h) Clearance CL (mL/hr/kg)
Intravenous injection (Males) 50 46000000 1320000 0.167 104 0.985
Intravenous injection (Females) 50 43300000 1020000 0.211 97.4 1.06
Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Dose normalize exposure AUC0-336 h (norm) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h)
Subcutaneous injection (Males) 0.5 676000 1350000 3190 50.0 120
Subcutaneous injection (Females) 0.5 445000 890000 2880 48.0 108
Subcutaneous injection (Males) 5 3940000 788000 22700 40.0 117
Subcutaneous injection (Females) 5 3840000 767000 23800 12.0 109
Subcutaneous injection (Males) 50 41600000 832000 272000 40.0 122
Subcutaneous injection (Females) 50 32300000 646000 212000 32.0 107

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
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SMILES

[Placulumab]
Storage

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Purity & Documentation
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Placulumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Placulumab945781-29-3ART621 CEP-37247 PN0621ART 621ART-621CEP37247CEP 37247CEP-37247PN0621PN 0621PN-0621TNF ReceptorTumor Necrosis Factor ReceptorTNFRNS0PBMCMouseInhibitorinhibitorinhibit

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