Anti-inflammatory agent 52
Anti-inflammatory agent 52 (compound 7j) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3052814-85-1
- 分子式: C24H21ClN2O3S
- 分子量:452.95
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
COX-2[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.18 μM
Compound: 7j
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Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
| HT-29 | IC50 |
0.02 μM
Compound: 7j
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Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
| MCF7 | IC50 |
0.11 μM
Compound: 7j
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Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
| MRC5 | IC50 |
0.47 μM
Compound: 7j
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Cytotoxicity against human MRC5 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
体外実験
Anti-inflammatory agent 52 (compound 7j) (0.25 μM; 24 h) inhibits colonies formation of HT29 cells, arrests cell cycle at G2/M phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
化学情報
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CAS 番号 3052814-85-1
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分子量 452.95
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分子式 C24H21ClN2O3S
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SMILES
O=C(COC1=CC=C(C=C1)N2C(SCC2=O)C3=CC=C(C=C3)C)NC4=CC=C(C=C4)Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anti-inflammatory agent 52 関連分類
HY-155780 関連分類
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