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Cat. No.: HY-149082

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LTB4 antagonist 1

LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC₅₀ of 288 nM. LTB4 antagonist 1 has significant anti-inflammatory properties.

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CAS No.: 2929239-84-7
화학식: C₂₆H₂₃NO₆
분자량:445.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

LTB4 antagonist 1 Chemical Structure

CAS No.: 2929239-84-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC₅₀ of 288 nM. LTB4 antagonist 1 has significant anti-inflammatory properties^[1].

IC₅₀ & Target

^[1]

LTB₄

All Leukotriene Receptor Isoforms :

In Vivo

LTB4 antagonist 1 (compound 24b; 30 mg/kg; orally) has a significant anti-inflammatory activity after 1 h in the model of podal edema with carrageenan in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

The model of podal edema with carrageenan in rats^[1]
Dosage:

30 mg/kg
Administration:

Orally; single dose
Result:

After 1 h, a significant anti-inflammatory activity was observed (percentage inhibition of the edema: 39.7%) on carrageenan compared to the control group.
After 2 h, the anti-inflammatory activity decreases sharply (16.2%).
This activity completely disappeared after 4 h under TUKEY test.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

CAS No. 2929239-84-7
분자량 445.46
화학식 C₂₆H₂₃NO₆
SMILES

CN(C(C1=C(OC2=CC(OCC3=CC=CC=C3)=CC=C2O1)C(O)=O)=O)CCC4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Latifa Bouissane, et al. New and promising type of leukotriene B4 (LTB4) antagonists based on the 1,4-benzodioxine structure. Eur J Med Chem. 2023 Apr 6;254:115332. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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