1. Immunology/Inflammation
    Apoptosis
  2. COX
    Apoptosis
  3. Flurbiprofen

Flurbiprofen (Synonyms: dl-Flurbiprofen)

Cat. No.: HY-10582 Purity: 99.92%
Handling Instructions

Flurbiprofen is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor, can be used for the research of colorectal cancer.

For research use only. We do not sell to patients.

Flurbiprofen Chemical Structure

Flurbiprofen Chemical Structure

CAS No. : 5104-49-4

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10 mM * 1 mL in DMSO USD 66 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Flurbiprofen is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor, can be used for the research of colorectal cancer[1][2][3].

IC50 & Target[1]

COX

 

COX-1

 

COX-2

 

In Vitro

Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2[1].
Flurbiprofen (2-20 nM; 12-48 hours) significantly decreases SW620 cell proliferation in a concentration- and time-dependent manner[1].
Flurbiprofen (10 nM; 24 hours) decreases COX2 expression[1].
Flurbiprofen (10 nM; 24 hours) inhibits the expression of inflammatory factors by inhibiting COX2[1].
Flurbiprofen (10 nM; 24 hours) promotes the apoptosis of colorectal cancer cells by inhibiting COX2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SW620 cells
Concentration: 2 nM, 4 nM, 10 nM, 20 nM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Inhibited colorectal cancer cell proliferation.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 10 nM
Incubation Time: 24 hours
Result: Significantly decreased the protein and mRNA levels of COX2.

RT-PCR[1]

Cell Line: SW620 cells
Concentration: 10 nM
Incubation Time: 24 hours
Result: Decreased COX2 mRNA expression levels

Apoptosis Analysis[1]

Cell Line: SW620 cells
Concentration: 10 nM
Incubation Time: 24 hours
Result: Significantly decreased the expression of Bcl2 and significantly increased the expression of Bax and cleaved-caspase3, with no effect on total caspase-3.
In Vivo

Flurbiprofen (0.3-4.8 mg/kg; p.o.; 4-5 dosages) has acute anti-inflammatory in adrenalectomized rats[2].
Flurbiprofen (10 mg/kg; i.p.; daily; for 6 days) attenuating high-fat diet-induced obesity in mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[2]
Dosage: 0.3 mg/kg, 0.6 mg/kg, 1.2 mg/kg, 2.4 mg/kg, 4.8 mg/kg
Administration: Oral administration, 4-5 dosages
Result: Inhibits the acute inflammation of adrenalectomized rats.
Clinical Trial
Molecular Weight

244.26

Formula

C₁₅H₁₃FO₂

CAS No.

5104-49-4

SMILES

FC1=C(C2=CC=CC=C2)C=CC(C(C)C(O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (409.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0940 mL 20.4700 mL 40.9400 mL
5 mM 0.8188 mL 4.0940 mL 8.1880 mL
10 mM 0.4094 mL 2.0470 mL 4.0940 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

Flurbiprofendl-FlurbiprofenCOXApoptosisCyclooxygenasenonsteroidalanti-inflammatoryagent NSAIANSAIDosteoarthritisrheumatoidarthritisInhibitorinhibitorinhibit

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