1. Immunology/Inflammation
  2. COX
    PGE synthase
  3. (S)-Flurbiprofen

(S)-Flurbiprofen (Synonyms: Esflurbiprofen)

Cat. No.: HY-15123 Purity: 99.83% ee.: 99.02%
Handling Instructions

(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively.

For research use only. We do not sell to patients.

(S)-Flurbiprofen Chemical Structure

(S)-Flurbiprofen Chemical Structure

CAS No. : 51543-39-6

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Description

(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively[1].

IC50 & Target[1]

COX-1

0.48 μM (IC50)

COX-2

0.47 μM (IC50)

In Vitro

(S)-Flurbiprofen (10–7 M) results in a total suppression of basal and stimulated PGE2 release in rat skin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

244.26

Formula

C₁₅H₁₃FO₂

CAS No.

51543-39-6

SMILES

O=C(O)[[email protected]@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (409.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0940 mL 20.4700 mL 40.9400 mL
5 mM 0.8188 mL 4.0940 mL 8.1880 mL
10 mM 0.4094 mL 2.0470 mL 4.0940 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(S)-FlurbiprofenEsflurbiprofenCOXPGE synthaseCyclooxygenaseProstaglandin E synthaseInhibitorinhibitorinhibit

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Product Name:
(S)-Flurbiprofen
Cat. No.:
HY-15123
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