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U-74389G  (Synonyms: PNU74389G (meleate))

Cat. No.: HY-106592A Purity: 98.64%
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U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity.

For research use only. We do not sell to patients.

U-74389G Chemical Structure

U-74389G Chemical Structure

CAS No. : 153190-29-5

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10 mg USD 65 In-stock
25 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

U-74389G Related Antibodies

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Description

U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].

In Vitro

U-74389G (12.5, 25 and 50 μM; 24 h) inhibits nitrite production in endotoxin stimulated peritoneal macrophages[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

U-74389G Related Antibodies

Cell Viability Assay[3]

Cell Line: Peritoneal macrophages
Concentration: 12.5, 25 and 50 μM
Incubation Time: 24 hours
Result: Reduced the nitrite concentrations in the supernatants of LPS-primed macrophages in a dose-dependent manner.
In Vivo

U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change[2].
U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of trinitrobenzenesulfonic acid-induced colitis[2]
Dosage: 10 mg/kg
Administration: Intravenous injection; 10 mg/kg; once daily; 6 d
Result: Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.
Animal Model: Male Sprague–Dawley rats injected with Lipopolysaccharide[3]
Dosage: 15 or 30 mg/kg
Administration: Intravenous injection; 15 or 30 mg/kg
Result: Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).
Molecular Weight

726.90

Formula

C41H54N6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(/C=C\C(O)=O)=O.C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=O)([H])[C@@]7([H])C([C@@]8(C(CC7)=CC(C=C8)=O)C)=CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (137.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3757 mL 6.8785 mL 13.7570 mL
5 mM 0.2751 mL 1.3757 mL 2.7514 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3757 mL 6.8785 mL 13.7571 mL 34.3926 mL
5 mM 0.2751 mL 1.3757 mL 2.7514 mL 6.8785 mL
10 mM 0.1376 mL 0.6879 mL 1.3757 mL 3.4393 mL
15 mM 0.0917 mL 0.4586 mL 0.9171 mL 2.2928 mL
20 mM 0.0688 mL 0.3439 mL 0.6879 mL 1.7196 mL
25 mM 0.0550 mL 0.2751 mL 0.5503 mL 1.3757 mL
30 mM 0.0459 mL 0.2293 mL 0.4586 mL 1.1464 mL
40 mM 0.0344 mL 0.1720 mL 0.3439 mL 0.8598 mL
50 mM 0.0275 mL 0.1376 mL 0.2751 mL 0.6879 mL
60 mM 0.0229 mL 0.1146 mL 0.2293 mL 0.5732 mL
80 mM 0.0172 mL 0.0860 mL 0.1720 mL 0.4299 mL
100 mM 0.0138 mL 0.0688 mL 0.1376 mL 0.3439 mL
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U-74389G Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-74389G153190-29-5PNU74389G (meleate)Othersanti-inflammatory activityPeritoneal macrophagesInhibitorinhibitorinhibit

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