U-74389G
Based on 1 Customer Validation
U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity.
For research use only. We do not sell to patients.
- Purity: 99.08%
- CAS No.: 153190-29-5
- Formula: C41H54N6O6
- Molecular Weight:726.90
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
U-74389G (12.5, 25 and 50 μM; 24 h) inhibits nitrite production in endotoxin stimulated peritoneal macrophages[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Peritoneal macrophages
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Concentration:12.5, 25 and 50 μM
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Incubation Time:24 hours
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Result:Reduced the nitrite concentrations in the supernatants of LPS-primed macrophages in a dose-dependent manner.
U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat model of trinitrobenzenesulfonic acid-induced colitis[2]
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Dosage:10 mg/kg
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Administration:Intravenous injection; 10 mg/kg; once daily; 6 d
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Result:Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.
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Animal Model:Male Sprague–Dawley rats injected with Lipopolysaccharide[3]
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Dosage:15 or 30 mg/kg
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Administration:Intravenous injection; 15 or 30 mg/kg
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Result:Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).
Chemical Information
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CAS No. 153190-29-5
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Appearance Solid
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Molecular Weight 726.90
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Formula C41H54N6O6
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Color White to off-white
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SMILES
OC(/C=C\C(O)=O)=O.C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=O)([H])[C@@]7([H])C([C@@]8(C(CC7)=CC(C=C8)=O)C)=CC1
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Synonyms
PNU74389G (meleate)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (137.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. A M Perna, et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res. 1996 Jul-Aug;34(1-2):25-31. [Content Brief]
[2]. Georgios Antonios Margonis, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb;193(2):667-74. [Content Brief]
[3]. D Altavilla, et al. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. Eur J Pharmacol. 1999 Mar 12;369(1):49-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3757 mL | 6.8785 mL | 13.7571 mL | 34.3926 mL |
| 5 mM | 0.2751 mL | 1.3757 mL | 2.7514 mL | 6.8785 mL | |
| 10 mM | 0.1376 mL | 0.6879 mL | 1.3757 mL | 3.4393 mL | |
| 15 mM | 0.0917 mL | 0.4586 mL | 0.9171 mL | 2.2928 mL | |
| 20 mM | 0.0688 mL | 0.3439 mL | 0.6879 mL | 1.7196 mL | |
| 25 mM | 0.0550 mL | 0.2751 mL | 0.5503 mL | 1.3757 mL | |
| 30 mM | 0.0459 mL | 0.2293 mL | 0.4586 mL | 1.1464 mL | |
| 40 mM | 0.0344 mL | 0.1720 mL | 0.3439 mL | 0.8598 mL | |
| 50 mM | 0.0275 mL | 0.1376 mL | 0.2751 mL | 0.6879 mL | |
| 60 mM | 0.0229 mL | 0.1146 mL | 0.2293 mL | 0.5732 mL | |
| 80 mM | 0.0172 mL | 0.0860 mL | 0.1720 mL | 0.4299 mL | |
| 100 mM | 0.0138 mL | 0.0688 mL | 0.1376 mL | 0.3439 mL |
U-74389G Related Classifications
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