153190-29-5
Chemical Structure
U-74389G
Synonym(s): PNU74389G (meleate)
- CAS No.: 153190-29-5
- Formula:C41H54N6O6
- Molecular Weight:726.90
IUPAC Name: (8S,10S,13S,14S,17S)-17-(2-(4-(2,6-di(pyrrolidin-1-yl)pyrimidin-4-yl)piperazin-1-yl)acetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one maleate
InChIKey: ABCSSKWSUJMJCP-WQDFMEOSSA-N
SMILES: OC(/C=C\C(O)=O)=O.C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=O)([H])[C@@]7([H])C([C@@]8(C(CC7)=CC(C=C8)=O)C)=CC1
Biological Activity: U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].
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U-74389G | 99.08% | U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity. | ||||||||||||||||||||
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- [1]. A M Perna, et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res. 1996 Jul-Aug;34(1-2):25-31. [Content Brief]
- [2]. Georgios Antonios Margonis, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb;193(2):667-74. [Content Brief]
- [3]. D Altavilla, et al. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. Eur J Pharmacol. 1999 Mar 12;369(1):49-55. [Content Brief]
Keywords
