1. Stem Cell/Wnt
  2. Hedgehog
    Smo
  3. Jervine

Jervine (Synonyms: 11-Ketocyclopamine)

Cat. No.: HY-N0836 Purity: 99.03%
Handling Instructions

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties.

For research use only. We do not sell to patients.

Jervine Chemical Structure

Jervine Chemical Structure

CAS No. : 469-59-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
5 mg USD 125 In-stock
Estimated Time of Arrival: December 31
10 mg USD 225 In-stock
Estimated Time of Arrival: December 31
50 mg USD 900 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum album. Jervine has anti-inflammatory and antioxidant properties[2].

IC50 & Target

IC50: 500-700 nM (Hedgehog)[1]

In Vitro

Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation[3].
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis[3].

Western Blot Analysis[1]

Cell Line: HEL and TF1a cells
Concentration: 40 μM
Incubation Time: 6, 12 and 24 hours
Result: Inhibited Akt phosphorylation.
In Vivo

Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema[2].

Animal Model: Male Sprague Dawley rats (180-200  g)[2]
Dosage: 50, 100, 200 and 400  mg/kg
Administration: Orally
Result: Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.
Molecular Weight

425.60

Formula

C₂₇H₃₉NO₃

CAS No.

469-59-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (2.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3496 mL 11.7481 mL 23.4962 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Jervine11-KetocyclopamineHedgehogSmoSmoothenedHhteratogenicsterodialalkaloidrhizomesVeratrumalbumanti-inflammatoryantioxidantInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Jervine
Cat. No.:
HY-N0836
Quantity:
MCE Japan Authorized Agent: