1. Stem Cell/Wnt
  2. Hedgehog
    Smo

Jervine (Synonyms: 11-Ketocyclopamine)

Cat. No.: HY-N0836 Purity: 99.03%
Handling Instructions

Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.

For research use only. We do not sell to patients.
Jervine Chemical Structure

Jervine Chemical Structure

CAS No. : 469-59-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
5 mg USD 150 In-stock
10 mg USD 270 In-stock
50 mg USD 1080 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. IC50 value: Target: sonic hedgehog is derived from the Veratrum plant species. It is a close structural analog of cyclopamine which specifically inhibits the hedgehog (Hh) pathway by interaction with the hedgehog signaling protein Smo. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Jervine is an inhibitor of Smo.

References
Molecular Weight

425.6

Formula

C₂₇H₃₉NO₃

CAS No.

469-59-0

SMILES

O=C1[[email protected]]2([H])[[email protected]]3(C)C(C[[email protected]@H](O)CC3)=CC[[email protected]@]2([H])[[email protected]]4([H])CC[[email protected]]5(O[[email protected]@]6([H])[[email protected]@]([[email protected]]5C)([H])NC[[email protected]@H](C)C6)C(C)=C41

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Jervine
Cat. No.:
HY-N0836
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