Jervine (Standard)
Jervine (Standard) (11-Ketocyclopamine (Standard)) is the analytical standard of Jervine (HY-N0836). This product is intended for research and analytical applications. Jervine (11-Ketocyclopamine) is an orally active steroidal alkaloid and Hedgehog signaling pathway inhibitor. Jervine can be isolated from Veratrum californicum. Jervine regulates Wnt, inhibits the AKT/mTOR signaling pathway, and activates the AMPK signaling pathway. Jervine induces DNA damage, Apoptosis, Autophagy, ROS production and Mitochondrial damage. Jervine exhibits anti-cancer and anti-inflammatory activities. Jervine reduces tumor growth rate and weight in xenograft models. Jervine can be used in studies related to triple-negative breast cancer, nasopharyngeal carcinoma and non-small cell lung cancer.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 469-59-0
- Formula: C27H39NO3
- Molecular Weight:425.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 469-59-0
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Molecular Weight 425.60
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Formula C27H39NO3
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SMILES
O=C1[C@]2([H])[C@]3(C)C(C[C@@H](O)CC3)=CC[C@@]2([H])[C@]4([H])CC[C@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)C(C)=C41
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Synonyms
11-Ketocyclopamine (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Jervine (Standard) Related Classifications
HY-N0836R Related Classifications
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Keywords
- Jervine (Standard)
- 469-59-0
- 11-Ketocyclopamine (Standard)
- Reference Standards
- Hedgehog
- Wnt
- Akt
- mTOR
- AMPK
- DNA/RNA Synthesis
- Apoptosis
- Autophagy
- Reactive Oxygen Species (ROS)
- Mitochondrial Metabolism
- PKB
- Protein kinase B
- Mammalian target of Rapamycin
- AMP-activated protein kinase
- LRP6
- 5-8F cells
- WNT5A
- nasopharyngeal carcinoma
- BMP4
- triple-negative breast cancer
- DVL2
- non-small cell lung cancer
- SHH
- FZD5
- Inhibitor
- inhibitor
- inhibit