1. Saccharides and Glycosides
  2. IKarisoside A

IKarisoside A (Synonyms: Icarisoside-A; Baohuoside II)

Cat. No.: HY-N0875 Purity: 99.27%
Handling Instructions

IKarisoside A(Icarisoside-A) is a natural compound isolated from Epimedium koreanum (Berberidaceae); has anti-inflammatory properties.

For research use only. We do not sell to patients.

IKarisoside A Chemical Structure

IKarisoside A Chemical Structure

CAS No. : 55395-07-8

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5 mg USD 780 In-stock
Estimated Time of Arrival: December 31
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IKarisoside A(Icarisoside-A) is a natural compound isolated from Epimedium koreanum (Berberidaceae); has anti-inflammatory properties. IC50 value: Target: in vitro: Ikarisoside A inhibited the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and mouse bone marrow-derived macrophages (BMMs) in a concentration-dependent manner. In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Furthermore, Ikarisoside A inhibited the activity of p38 kinase and nuclear factor-kappaB (NF-kappaB) [1]. Ikarisoside A is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW 264.7 cells as well as in bone marrow-derived macrophages.The inhibitory effect of Ikarisoside A resulted in decrease of osteoclast-specific genes like matrix metalloproteinase 9 (MMP9), tartrate-resistant acid phosphatase (TRAP), receptor activator of NF-kappaB (RANK), and cathepsin K. Moreover, Ikarisoside A blocked the resorbing capacity of RAW 264.7 cells on calcium phosphate-coated plates. Ikarisoside A also has inhibitory effects on the RANKL-mediated activation of NF-kappaB, JNK, and Akt [2].

Molecular Weight





OC1=CC(O)=C2C(OC(C3=CC=C(O)C=C3)=C(O[[email protected]](O[[email protected]@H](C)[[email protected]](O)[[email protected]]4O)[[email protected]@H]4O)C2=O)=C1C/C=C(C)\C


Room temperature in continental US; may vary elsewhere.


4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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IKarisoside AIcarisoside-A Baohuoside IIOthersInhibitorinhibitorinhibit

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