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United States

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Cat. No.: HY-N11624

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Axinelline A

Axinelline A is a potent COX inhibitor with IC₅₀s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity.

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CAS No.: 1593741-99-1
화학식: C₁₂H₁₅NO₆
분자량:269.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Axinelline A Chemical Structure

CAS No.: 1593741-99-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Axinelline A is a potent COX inhibitor with IC₅₀s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity^[1].

IC₅₀ & Target

^[1]

COX-2

2.22 μM (IC₅₀)

COX-1

8.89 μM (IC₅₀)

All COX Isoforms :

In Vitro

Axinelline A (2-30 μM; 24 h) inhibits Lipopolysaccharide (LPS; HY-D1056)-induced expression of pro-inflammatory factors (NO, TNF-α, IL-6, IL-1β, and PGE₂) in RAW264.7 cells^[1].
Axinelline A (2-30 μM; 24 h) inhibits LPS-induced NF-κB signaling pathway in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

RAW264.7 cells
Concentration:

2, 10 and 30 μM
Incubation Time:

24 h
Result:

Diminished LPS-induced expression of nitric oxide synthase (iNOS) and COX-2 protein levels. The phosphorylation level of NF-κB increased after 30 min of LPS treatment, but pretreatment with test compound reduced the level of phosphorylation in a dose-dependent manner. The phosphorylation of IKK and IκBα was inhibited in a dose-dependent manner.

Chemical Information

CAS No. 1593741-99-1
분자량 269.25
화학식 C₁₂H₁₅NO₆
SMILES

CCOC([C@H](CO)NC(C1=C(C(O)=CC=C1)O)=O)=O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Streptomyces axinellae
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ju Z, et al. Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues. J Nat Prod. 2023 Apr 28;86(4):958-965. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Axinelline A

All COX Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Axinelline A Related Classifications

HY-N11624 Related Classifications

Bioz

Keywords

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