2. Apoptosis Autophagy
  3. Apoptosis Autophagy
  4. Isoangustone A

Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death.

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Isoangustone A Chemical Structure

Isoangustone A Chemical Structure

CAS No. : 129280-34-8

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Isoangustone A Related Antibodies

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Description

Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death[1][2][3].

IC50 & Target

Apoptosis, Autophagy[2]
In Vitro

Isoangustone A (10 and 20 μM; 48 and 72 h) suppresses proliferation and induces G1 phase cell cycle arrest in SK-MEL-28 cells[1].
Isoangustone A (10 and 20 μM; 48 h) decreases the abundance of G1 phase-related proteins mediated through the Akt/GSK3β and MKK4/MKK7/JNKs signaling pathways[1].
Isoangustone A suppresses PI3-K, MKK4, and MKK7 kinase activities by directly binding in an ATP-competitive manner[1].
Isoangustone A (20 μM; 0.5-4 h) induces autophagy in colorectal cancer cells by activating AMPK signaling[2].
Isoangustone A (1-20 μM; 0-100 min) inhibits mitochondrial respiration[2].
Isoangustone A (15 μM; 6 h) induces SW480 cells apoptosis[2].
Isoangustone A (1-20 μΜ; 3 days) suppresses mesangial fibrosis and inflammation in human renal mesangial cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isoangustone A Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 and 72 h
Result: Inhibited proliferation in a dose- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: Caused cell cycle arrest at G1 phase.

Western Blot Analysis[1]

Cell Line: SK-MEL-28
Concentration: 10 and 20 μM
Incubation Time: 48 h
Result: Inhibited the expression of cyclin D1 and cyclin E. Suppressed phosphorylation of Rb in a dose-dependent manner. Inhibited the phosphorylation of Akt (Ser473, Thr308) and GSK3β (Ser9). Suppressed the phosphorylation of JNK1/2, but had no effect on ERK1/2 or p38.

Cell Autophagy Assay[2]

Cell Line: SW480 cells
Concentration: 20 μM
Incubation Time: 0.5, 2 and 4 h
Result: Deformed mitochondria, nondegradable cellular debris were all observable together with autophagic vacuoles in cells after 4 h.

Apoptosis Analysis[2]

Cell Line: SW480 cells
Concentration: 15 μM
Incubation Time: 6 h
Result: Induced elevation of apoptotic Annexin V+/PI- and Annexin V+/PI+ cell populations.
In Vivo

Isoangustone A (2 or 10 mg/kg; i.p.; daily for 35 days) significantly decreases tumor growth, volume, and weight of SK-MEL-28 xenografts in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb/c nu/nu mice, SK-MEL-28 xenograft model[1]
Dosage: 2 or 10 mg/kg
Administration: Intraperitoneal injection, daily for 35 days
Result: Significantly suppressed tumor weight compared to the control group. Markedly inhibited the expression of proliferating cell nuclear antigen (PCNA). Decreased phosphorylation levels of Akt.
Molecular Weight

422.47

Formula

C25H26O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(O)C(C/C=C(C)/C)=C(O)C=C2OC=C1C3=CC(C/C=C(C)/C)=C(O)C(O)=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥96.0%

COA (246 KB)

Handling Instructions (2659 KB)
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Isoangustone A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoangustone A129280-34-8ApoptosisAutophagySK-MEL-28PI3-KMKK4MKK7colorectal cancerSW480fibrosisinflammationhuman renal mesangial cellsInhibitorinhibitorinhibit

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