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  3. CP-868388 free base

CP-868388 free base 

Cat. No.: HY-116699
Handling Instructions

CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.

For research use only. We do not sell to patients.

CP-868388 free base Chemical Structure

CP-868388 free base Chemical Structure

CAS No. : 702681-67-2

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Description

CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions[1].

IC50 & Target[1]

hPPARα

10.8 nM (Ki)

hPPARγ

3.47 μM (Ki)

In Vitro

CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC50 of 4.7 nM) and PGC-1α peptide[1].
CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC50 of 18 nM in HepG2 cells[1].

In Vivo

CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%[1].

Animal Model: Male B6/CBF1J mice[1]
Dosage: 0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral gavage; once daily; for 2 days
Result: Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.
Molecular Weight

439.54

Formula

C₂₆H₃₃NO₅

CAS No.

702681-67-2

SMILES

O=C(N1C[[email protected]](C2=CC=CC(OC(C)(C(O)=O)C)=C2)CCC1)OCC3=CC=C(C(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CP-868388CP868388CP 868388PPARPeroxisome proliferator-activated receptorsPPARαhypolipidemicrecruitmentanti-inflammatorypiperidinetriglyceridePGC-1αSRC-1transcriptionalInhibitorinhibitorinhibit

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CP-868388 free base
Cat. No.:
HY-116699
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