SIRT5 inhibitor 7
Based on 1 Customer Validation
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 2951090-00-7
- Formula: C28H32ClN7O3S
- Molecular Weight:582.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 310 nM (SIRT5)[1]
Chemical Information
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CAS No. 2951090-00-7
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Appearance Solid
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Molecular Weight 582.12
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Formula C28H32ClN7O3S
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Color White to light yellow
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SMILES
S=C(NCCCNC1=NC(NC2=C(Cl)C=CC=C2)=NC=C1C(N3C[C@@H](C4=CC=CC=C4)CC3)=O)NCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (85.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7179 mL | 8.5893 mL | 17.1786 mL | 42.9465 mL |
| 5 mM | 0.3436 mL | 1.7179 mL | 3.4357 mL | 8.5893 mL | |
| 10 mM | 0.1718 mL | 0.8589 mL | 1.7179 mL | 4.2946 mL | |
| 15 mM | 0.1145 mL | 0.5726 mL | 1.1452 mL | 2.8631 mL | |
| 20 mM | 0.0859 mL | 0.4295 mL | 0.8589 mL | 2.1473 mL | |
| 25 mM | 0.0687 mL | 0.3436 mL | 0.6871 mL | 1.7179 mL | |
| 30 mM | 0.0573 mL | 0.2863 mL | 0.5726 mL | 1.4315 mL | |
| 40 mM | 0.0429 mL | 0.2147 mL | 0.4295 mL | 1.0737 mL | |
| 50 mM | 0.0344 mL | 0.1718 mL | 0.3436 mL | 0.8589 mL | |
| 60 mM | 0.0286 mL | 0.1432 mL | 0.2863 mL | 0.7158 mL | |
| 80 mM | 0.0215 mL | 0.1074 mL | 0.2147 mL | 0.5368 mL |
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