1. Apoptosis
    Autophagy
  2. Apoptosis
    Autophagy
  3. Aloperine

Aloperine 

Cat. No.: HY-13516
Handling Instructions

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.

For research use only. We do not sell to patients.

Aloperine Chemical Structure

Aloperine Chemical Structure

CAS No. : 56293-29-9

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Description

Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1].

In Vitro

Aloperine (1-20 mM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively[1].
Aloperine (1-20 mM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells[1].
Aloperine (20–100 mM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells[1].

Molecular Weight

232.36

Formula

C₁₅H₂₄N₂

CAS No.

56293-29-9

SMILES

[H][[email protected]]1(C2)[[email protected]](CCCC3)([H])N3C[[email protected]]2([H])[[email protected]@]4([H])C(CCCN4)=C1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Aloperine
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