56293-29-9
56293-29-9
Chemical Structure
Aloperine
- CAS No.: 56293-29-9
- Formula:C15H24N2
- Molecular Weight:232.37
IUPAC Name: (6R,6aR,13R,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-dodecahydro-2H-6,13-methanodipyrido[1,2-a:3',2'-e]azocine
InChIKey: SKOLRLSBMUGVOY-GBJTYRQASA-N
SMILES: [H][C@]1(C2)[C@](CCCC3)([H])N3C[C@]2([H])[C@@]4([H])C(CCCN4)=C1
Biological Activity: Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aloperine | 99.80% | Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells. | ||||||||||||||||||||
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Aloperine (Standard) | ≥98% | Aloperine (Standard) is the analytical standard of Aloperine. This product is intended for research and analytical applications. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells. | ||||||||||||||||||||
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Leontine | Leontine is a biochemical assay reagent. | |||||||||||||||||||||
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Allomatrine | 99.98% | Allomatrine ((+)-Allomatrine) is an alkaloid from the bark of Sophora japonica. Allomatrine has antinociceptive properties mediated mainly through the activation ofκ-opioid receptors. | ||||||||||||||||||||
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Matrine | 99.90% | Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI). | ||||||||||||||||||||
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(-)-Sparteine sulfate | (-)-Sparteine sulfate ((-)-Lupinidine sulfate) is a chiral proton base and catalytic promoter. (-)-Sparteine sulfate promotes the enantioselective carbolithiation of cinnamyl derivatives with primary and secondary organolithium reagents. (-)-Sparteine sulfate forms mixed aggregates with lithium halides. As an exogenous chiral base, (-)-Sparteine sulfate deprotonates palladium-bound secondary alcohols, promotes the formation of palladium-alkoxide species, and alters the rate-limiting step of the catalytic cycle, thereby affecting reaction rate and enantioselectivity. | |||||||||||||||||||||
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Sophoridine (Standard) | ≥98% | Sophoridine (Standard) is the analytical standard of Sophoridine. This product is intended for research and analytical applications. Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity. | ||||||||||||||||||||
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Lupanine | 98.2% | Lupanine (D-Lupanine) is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine shows binding affinity for nicotinic receptor with a Ki value of 500 nM. | ||||||||||||||||||||
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Lupanine hydrochloride | Lupanine (D-Lupanine) hydrochloride is a natural ketonic derivative of Sparteine (HY-W008350) with a ganglioplegic activity. Lupanine hydrochloride shows binding affinity for nicotinic receptor with a Ki value of 500 nM. | |||||||||||||||||||||
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Sparteine | Sparteine (Lupinidine) is an alkaloid compound derived from leguminous plants and can act as a ganglionic blocker. Sparteine competitively inhibits the activity of the neuronal nicotinic acetylcholine receptor (nACh receptor). | |||||||||||||||||||||
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(+)-Sparteine (Standard) | ≥98% | (+)-Sparteine (Standard) is the analytical standard of (+)-Sparteine (HY-W008350). This product is intended for research and analytical applications. (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. | ||||||||||||||||||||
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(-)-Sparteine hydroiodide | (-)-Sparteine hydroiodide ((-)-Lupinidine hydroiodide) is a chiral proton base and catalytic promoter. (-)-Sparteine hydroiodide promotes the enantioselective carbolithiation of cinnamyl derivatives with primary and secondary organolithium reagents. (-)-Sparteine hydroiodide forms mixed aggregates with lithium halides. As an exogenous chiral base, (-)-Sparteine hydroiodide deprotonates palladium-bound secondary alcohols, promotes the formation of palladium-alkoxide species, and alters the rate-limiting step of the catalytic cycle, thereby affecting reaction rate and enantioselectivity. | |||||||||||||||||||||
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References
- [1]. Lin Z, et al. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011 May;108(5):304-9. [Content Brief]
- [2]. Yuan XY, et al. Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010 Mar 10;629(1-3):147-52. [Content Brief]
