1. GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. Opioid Receptor
    Autophagy
    Mitophagy
  3. Matrine

Matrine (Synonyms: Matridin-15-one; Vegard; α-Matrine)

Cat. No.: HY-N0164 Purity: >98.0%
Handling Instructions

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.

For research use only. We do not sell to patients.

Matrine Chemical Structure

Matrine Chemical Structure

CAS No. : 519-02-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
200 mg USD 160 In-stock
Estimated Time of Arrival: December 31
500 mg USD 320 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Matrine

    Matrine purchased from MCE. Usage Cited in: Exp Ther Med. 2019 May;17(5):3775-3780.

    Matrine promotes the nuclear Foxo3a localization and inhibits the levels of cytoplasmic Foxo3a. RC‑4B/C cells are treated with increasing concentrations of matrine for 24 h. The levels of Foxo3 are determined by western blotting analysis. β‑tubulin is used as cytoplasmic marker and lamin B1 is used as nuclear marker in RC‑4B/C cells. The gray values of Foxo3a is shown in histogram in different concentrations of matrine‑treated pituitary cancer cells.

    Matrine purchased from MCE. Usage Cited in: Exp Ther Med. 2019 May;17(5):3775-3780.

    Matrine increases the expression of pro‑apoptotic proteins in RC‑4B/C cells. RC‑4B/C cells are treated with 0.1, 0.5 and 2.5 mg/ml of matrine for 24 h and the expression of Bim, Bax and Bcl‑2 is determined by western blotting analysis. RC‑4B/C cells treated with 0.1% DMSO are used as negative controls. β‑actin is used as internal reference gene in pituitary cancer cells.
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    Description

    Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.

    Molecular Weight

    248.36

    Formula

    C₁₅H₂₄N₂O

    CAS No.

    519-02-8

    SMILES

    O=C1CCC[[email protected]]2([H])[[email protected]@]3([H])CCCN4[[email protected]@]3([H])[[email protected]](CCC4)([H])CN21

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (201.32 mM)

    H2O : 20 mg/mL (80.53 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0264 mL 20.1321 mL 40.2641 mL
    5 mM 0.8053 mL 4.0264 mL 8.0528 mL
    10 mM 0.4026 mL 2.0132 mL 4.0264 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

    Keywords:

    MatrineMatridin-15-one Vegard α-MatrineOpioid ReceptorAutophagyMitophagyMitochondrial AutophagyInhibitorinhibitorinhibit

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    Product name:
    Matrine
    Cat. No.:
    HY-N0164
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