1. Neuronal Signaling
    GPCR/G Protein
    Autophagy
  2. Opioid Receptor
    Autophagy

Matrine (Synonyms: Sophocarpidine; Matridin-15-one; Vegard; α-Matrine)

Cat. No.: HY-N0164 Purity: >98.0%
Handling Instructions

Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus.

For research use only. We do not sell to patients.

Matrine Chemical Structure

Matrine Chemical Structure

CAS No. : 519-02-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 139 In-stock
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Estimated Time of Arrival: December 31
100 mg USD 126 In-stock
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Estimated Time of Arrival: December 31
200 mg USD 216 In-stock
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Estimated Time of Arrival: December 31
500 mg USD 384 In-stock
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Estimated Time of Arrival: December 31
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Matrine(Sophocarpidine; α-Matrine) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist. IC50 Value: 540 μg/ml (inhibit gastric cancer cell line MNK45, MTT) [1] Target: u-receptor/kappa opioid in vitro: MTT assay showed that the matrine was able to inhibit gastric cancer cell line MNK45 in a dose-dependent manner. The concentration required for 50% inhibition (IC50) was found to be 540 μg/ml. This anti-tumor function was achieved through modulation of the NF-κB, XIAP, CIAP, and p-ERK proteins expression in cell line MNK45. Matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose- and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC) [2]. in vivo: Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction [3]. high dose of matrine significantly reduced the mortality rate of mice with LPS administration. Treatment with matrine improved LPS-induced lung histopathologic changes, alleviated pulmonary edema and lung vascular leak, inhibited MPO and MDA activity,and reduced the production of inflammatory mediators including TNF-α, IL-6 and HMGB1 [4]. Toxicity: N/A Clinical trial: N/A

References
Molecular Weight

248.36

Formula

C₁₅H₂₄N₂O

CAS No.

519-02-8

SMILES

O=C1CCC[[email protected]]2([H])[[email protected]@]3([H])CCCN4[[email protected]@]3([H])[[email protected]](CCC4)([H])CN21

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Matrine
Cat. No.:
HY-N0164
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