Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives

  • Bioorg Med Chem Lett. 2012 Jun 15;22(12):4100-2. doi: 10.1016/j.bmcl.2012.04.069.
Lisheng Wang  1 ,  Yejun You ,  Songqing Wang ,  Xu Liu ,  Buming Liu ,  Jinni Wang ,  Xiao Lin ,  Mingsheng Chen ,  Gang Liang ,  Hua Yang
Affiliations
  • 1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People's Republic of China. [email protected]
PMID: 22578453 DOI: 10.1016/j.bmcl.2012.04.069
Abstract

Nineteen previously unreported matrine derivatives were synthesized and characterized using elemental analysis, infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and mass spectrometry. Target compounds 6a-6l and 7a-7c showed stronger inhibitory activities than matrine in the in vitro antitumor tests and inhibited the growth of the Hep7402, B16-F10, A549, and TW03 cell lines. In addition, compound 6i exhibited a potent antitumor activity similar to that of colchicine.