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(Rac)-Modipafant (Synonyms: UK-74505)

Cat. No.: HY-108908
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(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.

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(Rac)-Modipafant Chemical Structure

(Rac)-Modipafant Chemical Structure

CAS No. : 122956-68-7

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Description

(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection[1][2][3].

In Vivo

(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection[3].
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively)[4].
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia[5].

Animal Model: 8- to 10-week-old BALB/c mice (DEN-2 strain infected)[3]
Dosage: 10 mg/kg
Administration: P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10
Result: Decreased by approximately 50% the lethality associated with DEN-2 infection.
Animal Model: Male BALB/C (8- to 10- week-old) wild-type mice[5]
Dosage: 5, 10 and 20 mg/kg
Administration: P.o.
Result: Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.
Molecular Weight

605.09

Formula

C₃₄H₂₉ClN₆O₃

CAS No.

122956-68-7

SMILES

O=C(C1=C(C2=CC=C(N3C(C)=NC4=C3C=CN=C4)C=C2)NC(C)=C(C(NC5=NC=CC=C5)=O)C1C6=CC=CC=C6Cl)OCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(Rac)-ModipafantUK-74505UK74505UK 74505Othersselectivelong-actingirreversiblearticularinflammatoryhyperalgesiadengueinfectionInhibitorinhibitorinhibit

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(Rac)-Modipafant
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