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Coixol (Synonyms: 6-Methoxy-2-benzoxazolinone; 6-MBOA)

Cat. No.: HY-N0936 Purity: 98.51%
Handling Instructions

Coixol is a natural product extracted from Coix Lachryma-Jobi var.

For research use only. We do not sell to patients.

Coixol Chemical Structure

Coixol Chemical Structure

CAS No. : 532-91-2

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen. IC50 value: Target: In vitro: Confluent NCI-H292 cells were pretreated with oleic acid, linoleic acid, glyceryl trilinoleate, beta-stigmasterol or coixol for 30 min and then stimulated with PMA (phorbol 12-myristate 13-acetate), EGF (epidermal growth factor) or TNF-α (tumor necrosis factor-α) for 24 h. Coixol inhibited the expression of MUC5AC mucin gene and production of MUC5AC mucin protein, induced by EGF or TNF-α from NCI-H292 cells; Coixol decreased PMA-induced MUC5AC mucin secretion from NCI-H292 cells [1]. βTC-6 cells were incubated in 2 mM and 20 mM glucose in the presence of coixol (200 μM) for 60 min at 37°C in Krebs-Ringer Bicarbonate buffer. Decreased insulin staining was observed by coixol at 20 mM glucose (bottom) suggest that coixol stimulated insulin secretion at high glucose concentration [2]. In vivo:

Molecular Weight

165.15

Formula

C₈H₇NO₃

CAS No.

532-91-2

SMILES

O=C1OC2=CC(OC)=CC=C2N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (605.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0551 mL 30.2755 mL 60.5510 mL
5 mM 1.2110 mL 6.0551 mL 12.1102 mL
10 mM 0.6055 mL 3.0276 mL 6.0551 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (15.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (15.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Coixol6-Methoxy-2-benzoxazolinone6-MBOAOthersInhibitorinhibitorinhibit

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Coixol
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