532-91-2
532-91-2
Chemical Structure
Coixol
Synonym(s): 6-Methoxy-2-benzoxazolinone; 6-MBOA
- CAS No.: 532-91-2
- Formula:C8H7NO3
- Molecular Weight:165.15
IUPAC Name: 6-methoxybenzo[d]oxazol-2(3H)-one
InChIKey: MKMCJLMBVKHUMS-UHFFFAOYSA-N
SMILES: O=C1OC2=CC(OC)=CC=C2N1
Biological Activity: Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Coixol | 98.56% | Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level. | ||||||||||||||||||||
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Coixol (Standard) | 98.67% | Coixol (Standard) (6-Methoxy-2-benzoxazolinone (Standard)) is the analytical standard of Coixol (HY-N0936). This product is intended for research and analytical applications. Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level. | ||||||||||||||||||||
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Chlorzoxazone (Standard) | 99.81% | Chlorzoxazone (Standard) is the analytical standard of Chlorzoxazone. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Chlorzoxazone-13C | Chlorzoxazone-13C is the 13C labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | |||||||||||||||||||||
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Herniarin (Standard) | ≥98% | Herniarin (Standard) (Methylumbelliferone (Standard)) is the analytical standard of Herniarin (HY-N1366). This product is intended for research and analytical applications. Herniarin is a natural coumarin occurs in some flowering plants with anticancer effects. Herniarin results in a significant decrease in cell viability by inducing apoptosis in MCF-7 cells. Herniarin also has anti-dermatophytic activity. Herniarin can be used for the study of bladder cancer and breast cancer. | ||||||||||||||||||||
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5-Hydroxy-7-methoxycoumarin | 5-Hydroxy-7-methoxycoumarin is a coumarin compound present in the whole plant of Euphorbia kansuensis, with an IC50 > 40 μM against five human cancer cell lines. | |||||||||||||||||||||
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5-Methoxyindole | 99.92% | 5-Methoxyindole is an L-tryptophan metabolite with antifungal activity, and also serves as a pharmaceutical intermediate. Metabolites of 5-Methoxyindole exhibit COX-2 inhibitory, anti-inflammatory and anti-tumor activities. 5-Methoxyindole induces morphological distortion of hyphae and conidia, ROS accumulation, apoptosis and cell death in Gaeumannomyces graminis. 5-Methoxyindole can be used in studies related to fungal infections and organic synthesis. | ||||||||||||||||||||
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5-Methoxy-2-benzimidazolethiol | 99.55% | 5-Methoxy-2-benzimidazolethiol is a benzimidazole derivative. 5-Methoxy-2-benzimidazolethiol can serve as a ligand for transition metal complexes. | ||||||||||||||||||||
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2-Benzoxazolinone | 99.87% | 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. Derivatives as anti-quorum sensing agent. | ||||||||||||||||||||
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6-Chloro-2-benzoxazolinone | 99.12% | 6-Chloro-2-benzoxazolinone (6-Chlorobenzo[d]oxazol-2 (3H)-one) is a derivative of DIMBOA (HY-N7432) and an antibacterial agent. The minimum inhibitory concentration (MIC) of 6-Chloro-2-benzoxazolinone against Ralstonia solanacearum is 100 mg/L, and its minimum bactericidal concentration (MBC) is 500 mg/L. 6-Chloro-2-benzoxazolinone reduces biofilm formation and inhibits swarming motility of *Ralstonia solanacearum*. It can be used for the research of bacterial wilt. | ||||||||||||||||||||
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PIM-35 | PIM-35 is a derivative of Indole (HY-W001132). PIM-35 significantly inhibits serotonin (5HT) and dopamine (DA) uptake with a weak inhibitory effect on noradrenaline (NA) uptake.PIM-35 has antidepressant activity and can be used for depression research. | |||||||||||||||||||||
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6-Hydroxy Chlorzoxazone-13C6 | 6-Hydroxy Chlorzoxazone-13C6 is a the 13C-labeled 6-Hydroxy Chlorzoxazone (HY-W016221). 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | |||||||||||||||||||||
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References
- [1]. Yusheng Hu, et al. Coixol Suppresses NF-κB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells. Molecules [Content Brief]
- [2]. Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86(8):1950-1959. [Content Brief]
- [3]. Hameed A, et al. Coixol amplifies glucose-stimulated insulin secretion via cAMP mediated signaling pathway. Eur J Pharmacol. 2019 Sep 5;858:172514. [Content Brief]
