1. Anti-infection
  2. Parasite
  3. 2-Benzoxazolinone

2-Benzoxazolinone (Synonyms: 2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole)

Cat. No.: HY-W015818 Purity: >99.0%
Handling Instructions

2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. Derivatives as anti-quorum sensing agent.

For research use only. We do not sell to patients.

2-Benzoxazolinone Chemical Structure

2-Benzoxazolinone Chemical Structure

CAS No. : 59-49-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4].

IC50 & Target

LC50: 40 μg/mL (L. donovani)[1]

In Vitro

2-Benzoxazolinone (0.1-5 mM) induces oxidative stress in mung bean through generation of ROS and upregulation of activities of various scavenging enzymes[2].

Molecular Weight

135.12

Formula

C₇H₅NO₂

CAS No.

59-49-4

SMILES

O=C1OC2=CC=CC=C2N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (740.08 mM; Need ultrasonic)

H2O : 3.85 mg/mL (28.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.4008 mL 37.0041 mL 74.0083 mL
5 mM 1.4802 mL 7.4008 mL 14.8017 mL
10 mM 0.7401 mL 3.7004 mL 7.4008 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (18.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

2-Benzoxazolinone2-Benzoxazolone1,3-Benzoxazol-2(3H)-one2-HydroxybenzoxazoleParasiteInhibitorinhibitorinhibit

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Product name:
2-Benzoxazolinone
Cat. No.:
HY-W015818
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