59-49-4
59-49-4
Chemical Structure
2-Benzoxazolinone
Synonym(s): 2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole
- CAS No.: 59-49-4
- Formula:C7H5NO2
- Molecular Weight:135.12
IUPAC Name: benzo[d]oxazol-2(3H)-one
InChIKey: ASSKVPFEZFQQNQ-UHFFFAOYSA-N
SMILES: O=C1OC2=CC=CC=C2N1
Biological Activity: 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Benzoxazolinone | 99.87% | 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. Derivatives as anti-quorum sensing agent. | ||||||||||||||||||||
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2-Benzoxazolinone (Standard) | 98.56% | 2-Benzoxazolinone (Standard) is the analytical standard of 2-Benzoxazolinone. This product is intended for research and analytical applications. 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts. Derivatives as anti-quorum sensing agent. | ||||||||||||||||||||
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Isatoic anhydride | 99.26% | Isatoic anhydride is a single-adduct forming reagent and a monofunctional SHAPE reagent. Isatoic anhydride reacts with the 2'-hydroxyl group of RNA nucleotides via a single reactive group to form a single adduct, without forming cross-links between nucleotides. In SHAPE-JuMP experiments, Isatoic anhydride serves as a control reagent for single-adduct formation, which is used to distinguish true cross-links from single-adduct formation. | ||||||||||||||||||||
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Carsalam | 99.91% | Carsalam (Carbonylsalicylamide; 2H-1,3-benzoxazine-2,4-dione) is a salicylamide derivative and precursor compound. Carsalam is a nonsteroidal anti-inflammatory agent and can inhibit platelet aggregation. | ||||||||||||||||||||
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Chlorzoxazone | 99.77% | Chlorzoxazone is a SK-type potassium channel activator. Chlorzoxazone modulates FOXO3 phosphorylation and Aβ. Chlorzoxazone enhances immunosuppression, attenuates vasoconstriction, attenuates cognitive deficits, and improves experimental autoimmune encephalomyelitis. | ||||||||||||||||||||
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Chlorzoxazone-13C | Chlorzoxazone-13C is the 13C labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. | |||||||||||||||||||||
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Coixol | 98.56% | Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level. | ||||||||||||||||||||
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2-Hydroxybenzimidazole (Standard) | ≥98% | 2-Hydroxybenzimidazole (Standard) is the analytical standard of 2-Hydroxybenzimidazole (HY-W008003). This product is intended for research and analytical applications. 2-Hydroxybenzimidazole is a metabolite of Carbendazim (HY-13582). 2-Hydroxybenzimidazole is produced by the degradation of Carbendazim (HY-13582) by mycobacteria. 2-Hydroxybenzimidazole does not induce CYP1A1 protein expression and does not significantly reduce mortality in mice after influenza virus challenge following intranasal administration. 2-Hydroxybenzimidazole can be used in research on tobacco mosaic virus infection and influenza. | ||||||||||||||||||||
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2-Chlorobenzimidazole | 98.0% | 2-Chlorobenzimidazole is a pharmaceutical intermediate used in the synthesis of a series of derivatives with anti-human cytomegalovirus (HCMV) activity. 2-Chlorobenzimidazole can be used to form metal complexes (cobalt, copper, and zinc), with zinc complexes exhibiting significant anticancer activity. | ||||||||||||||||||||
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2-Chlorobenzoxazole | 98.0% | 2-Chlorobenzoxazole is a synthetic building block that can be used to synthesize a variety of active compounds. | ||||||||||||||||||||
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2-Methylbenzoxazole (Standard) | ≥98% | 2-Methylbenzoxazole (Standard) is the analytical standard of 2-Methylbenzoxazole (HY-W038287). This product is intended for research and analytical applications. 2-Methylbenzoxazole is a benzoxazole-type food flavor. 2-Methylbenzoxazole has phenolic, sweet, tobacco, and roasted meat aroma characteristics. 2-Methylbenzoxazole can be isolated from coffee, candy, cheese, and milk. 2-Methylbenzoxazole acts as a monodentate O-bonded ligand through the oxygen atom in Pd (II) and Pt (II) complexes. | ||||||||||||||||||||
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6-Chloro-2-benzoxazolinone | 99.12% | 6-Chloro-2-benzoxazolinone (6-Chlorobenzo[d]oxazol-2 (3H)-one) is a derivative of DIMBOA (HY-N7432) and an antibacterial agent. The minimum inhibitory concentration (MIC) of 6-Chloro-2-benzoxazolinone against Ralstonia solanacearum is 100 mg/L, and its minimum bactericidal concentration (MBC) is 500 mg/L. 6-Chloro-2-benzoxazolinone reduces biofilm formation and inhibits swarming motility of *Ralstonia solanacearum*. It can be used for the research of bacterial wilt. | ||||||||||||||||||||
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References
- [1]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8. [Content Brief]
- [3]. Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70(2):245-53. [Content Brief]
- [4]. Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62(7):330-4. [Content Brief]
