2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-17

BTK-IN-17 (compound 36R) is a selective and orally activeBTK inhibitor with an IC50 value of 13.7 nM. BTK-IN-17 decreases the expression of p-BTKY223 and p-PLCγ2Y1217. BTK-IN-17 shows anti-inflammatory effects.

For research use only. We do not sell to patients.

BTK-IN-17 Chemical Structure

BTK-IN-17 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

BTK-IN-17 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BTK-IN-17 (compound 36R) is a selective and orally activeBTK inhibitor with an IC50 value of 13.7 nM. BTK-IN-17 decreases the expression of p-BTKY223 and p-PLCγ2Y1217. BTK-IN-17 shows anti-inflammatory effects[1].

IC50 & Target

IC50: 13.7 nM (BTK)[1]
In Vitro

BTK-IN-17 (compound 36R) shows hERG channel inhibition with an IC50 value of 8.6 µM[1].
BTK-IN-17 (0-10000 nM) decreases the expression of p-BTKY223 and p-PLCγ2Y1217 in Ramos cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BTK-IN-17 Related Antibodies

Western Blot Analysis[1]

Cell Line: Ramos cells
Concentration: 0-10000 nM
Incubation Time:
Result: Inhibited phosphorylation of downstream BTK (p-BTKY223) and phosphorylation of PLCγ2 (p-PLCγ2Y1217).
In Vivo

BTK-IN-17 (1 mg/kg for i.v.; 10 mg/kg for p.o.) shows the plasma concentrations rapidly reached 125 nM and BTK occupancy reached 79%one hour after oral administration, target occupancy of roughly 62% was maintained after 24 h in rats[1].
BTK-IN-17 (10, 30, 50 mg/kg; p.o.; once daily for 10 days) shows good anti-inflammatory effects in rats[1].
Pharmacokinetic Parameters of BTK-IN-17 in Male Sprague-Dawley rats[1].

iv (1 mg/kg) po (10 mg/kg)
C0 (ng·mL-1) 786±121 -
C max (ng·mL-1) - 52.5±11.3
T1/2 (h) 0.73±0.05 1.67±0.27
Tmax (h) - 1.00±0.5
AUC(ng·h·mL-1) 454±25 164±18
CL (mL·kg-1·min-1) 36.8±2.0 -
Vdss (L·kg-1) 1.67±0.04 -
F (%) - 3.6±0.4
Sprague-Dawley rats, 1 mg/kg for i.v.; 10 mg/kg p.o.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

465.51

Formula

C26H23N7O2
SMILES

C=CC(N1CC[C@H](C1)N2N=C(C3=CNC4=NC=NC2=C34)NC5=CC=C(C=C5)OC6=CC=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BTK-IN-17 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-17BtkBruton tyrosine kinaseanti-inflammatoryhERG channelRamos cellsorally activep-BTKY223p-PLCγ2Y1217Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BTK-IN-17
Cat. No.:
HY-151920
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.