Anisodamine hydrobromide  (Synonyms: 6-Hydroxyhyoscyamine hydrobromide)

Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic and a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide shows antioxidant, anti-inflammatory properties^[1][2].

Nicotinic cholinoceptor^[1]

Anisodamine hydrobromide (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuated average fluorescence intensity of α-bungarotoxin binding compared with Ach alone^[2].
Anisodamine hydrobromide action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anisodamine hydrobromide (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

386.28

Solid

C₁₇H₂₄BrNO₄

55449-49-5

CN1[[email protected]]2[[email protected]@H](O)C[[email protected]@H]1C[[email protected]](OC([[email protected]@H](C3=CC=CC=C3)CO)=O)C2.Br

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Eisenkraft A. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016;173(11):1719-1727.  [Content Brief]

  [2]. Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37(2):634-641.  [Content Brief]