Etiprednol dicloacetate
Etiprednol dicloacetate (BNP 166) is an anti-inflammatory agent. Etiprednol dicloacetate inhibits eosinophil accumulation. Etiprednol dicloacetate can be used in the research of inflammatory airway diseases, such as asthma.
For research use only. We do not sell to patients.
- CAS No.: 199331-40-3
- Formula: C24H30Cl2O6
- Molecular Weight:485.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production by human blood[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Etiprednol dicloacetate (0.1 μg/kg, intranasal inhalation) inhibits eosinophil accumulation in rats (antigen-induced airway eosinophil infiltration)[3].
Etiprednol dicloacetate (0-20 mg/kg, p.o., 28 days) is well tolerated in rats and dogs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Allergen sensitized and challenged Brown Norway rats[1]
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Dosage:0.1, 1, 10, and 100 μg/kg
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Administration:Intranasal inhalation
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Result:Decreased the number of eosinophils at the perivascular area of the lung tissue.
Decreased the number of mucus secreting cells and antigen-induced formation of perivascular edema.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 199331-40-3
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Molecular Weight 485.40
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Formula C24H30Cl2O6
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SMILES
ClC(Cl)C(O[C@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([H])[C@@H](O)C2)([H])CC1)C)C(OCC)=O)=O
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Synonyms
BNP 166; Etiprednol dichloroacetate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. István Kurucz, et al. Potency and specificity of the pharmacological action of a new, antiasthmatic, topically administered soft steroid, etiprednol dicloacetate (BNP-166). J Pharmacol Exp Ther. 2003 Oct;307(1):83-92. [Content Brief]
[2]. A Miklós, et al. 28-day oral toxicity study with soft corticosteroid BNP-166 in rats and dogs, followed by a 14-day recovery period. Pharmazie. 2002 Feb;57(2):142-6. [Content Brief]
[3]. I Kurucz, et al. Anti-inflammatory effect and soft properties of etiprednol dicloacetate (BNP-166), a new, anti-asthmatic steroid. Pharmazie. 2004 May;59(5):412-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Etiprednol dicloacetate Related Classifications
HY-106215 Related Classifications
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