2. Cytoskeleton
  3. Gap Junction Protein
  4. Tonabersat

Tonabersat  (Synonyms: SB-220453)

Cat. No.: HY-15204 Purity: 98.36%
COA Handling Instructions

Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system.

For research use only. We do not sell to patients.

Tonabersat Chemical Structure

Tonabersat Chemical Structure

CAS No. : 175013-84-0

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 159 In-stock
Solution
10 mM * 1 mL in DMSO USD 159 In-stock
Solid
5 mg USD 145 In-stock
10 mg USD 232 In-stock
25 mg USD 510 In-stock
50 mg USD 820 In-stock
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Customer Review

Based on 14 publication(s) in Google Scholar

Tonabersat Related Antibodies

Top Publications Citing Use of Products

    Tonabersat purchased from MedChemExpress. Usage Cited in: Patent. US20170258758A1.

    ELISA of IFNα and TNFα in conditioned media from co-cultured MDA231-BrM2 cell and astrocytes in the presence of Tonabersat (Tona) with indicated concentrations.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3].

    IC50 & Target

    Gap-junction[1]
    In Vitro

    Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Tonabersat Related Antibodies
    In Vivo

    Tonabersat (10 mg/kg) significantly inhibits progression of metastatic lesions. Addition of NSC 241240 to either agent profoundly inhibits brain metastasis[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    391.82

    Appearance

    Solid

    Formula

    C20H19ClFNO4
    CAS No.
    SMILES

    O[C@@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[C@@H]1NC(C3=CC(Cl)=C(F)C=C3)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (255.22 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5522 mL 12.7610 mL 25.5219 mL
    5 mM 0.5104 mL 2.5522 mL 5.1044 mL
    10 mM 0.2552 mL 1.2761 mL 2.5522 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (6.38 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (6.38 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (6.38 mM); Clear solution

    • 4.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: ≥ 2.5 mg/mL (6.38 mM); Suspended solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
    Animal Administration
    [2]

    Mice[2]
    Athymic NCR nu/nu mice, Cr:NIH bg-nu-xid mice, B6129SF1/J, C57BL/6J-Tmem173gt/J 'golden ticket', and C57/Bl/6J mice are used at 5-6 weeks of age. For inducible knockdown experiments, mice are given WC2031 in the drinking water (2 mg/mL) and the diet 14 days after injection of cancer cells. For drug treatment experiments, mice are intraperitoneally injected with NSC 241240 (5 mg/kg per 5 days), Tonabersat (MedChem Express) (10 mg/kg per day), or meclofenamic acid sodium salt (20 mg/kg per day). Vehicle (10% DMSO in polyethylene glycol 400) is used in control mice. Quantification of tumour burden is by Bio-luminescent imaging (BLI), performed using an IVIS Spectrum Xenogen instrument and analysed using Living Image software v.2.50.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References
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    Tonabersat Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Tonabersat175013-84-0SB-220453SB220453SB 220453Gap Junction ProteinInhibitorinhibitorinhibit

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