1. Cytoskeleton
  2. Gap Junction Protein
  3. Tonabersat

Tonabersat (Synonyms: SB-220453)

Cat. No.: HY-15204 Purity: 99.68%
Handling Instructions

Tonabersat is a gap-junction modulator.

For research use only. We do not sell to patients.

Tonabersat Chemical Structure

Tonabersat Chemical Structure

CAS No. : 175013-84-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1  mL in DMSO USD 224 In-stock
Estimated Time of Arrival: December 31
5 mg USD 204 In-stock
Estimated Time of Arrival: December 31
10 mg USD 343 In-stock
Estimated Time of Arrival: December 31
50 mg USD 862 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Tonabersat purchased from MCE. Usage Cited in: Patent. US20170258758A1.

    ELISA of IFNα and TNFα in conditioned media from co-cultured MDA231-BrM2 cell and astrocytes in the presence of Tonabersat (Tona) or meclofenamate (Meclo) with indicated concentrations.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review


    Tonabersat is a gap-junction modulator.

    IC50 & Target


    In Vitro

    Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms[1].

    In Vivo

    Treatment with either Tonabersat (10 mg/kg) or Meclofenamate (20 mg/kg) as single agents significantly inhibit progression of metastatic lesions. Addition of carboplatin to either agent profoundly inhibits brain metastasis[2].

    Clinical Trial
    Molecular Weight




    CAS No.



    O[[email protected]@H]1C(C)(C)OC2=CC=C(C(C)=O)C=C2[[email protected]@H]1NC(C3=CC(Cl)=C(F)C=C3)=O


    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (255.22 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5522 mL 12.7610 mL 25.5219 mL
    5 mM 0.5104 mL 2.5522 mL 5.1044 mL
    10 mM 0.2552 mL 1.2761 mL 2.5522 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.38 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (6.38 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.38 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    Animal Administration

    Athymic NCR nu/nu mice, Cr:NIH bg-nu-xid mice, B6129SF1/J, C57BL/6J-Tmem173gt/J 'golden ticket', and C57/Bl/6J mice are used at 5-6 weeks of age. For inducible knockdown experiments, mice are given doxycycline hyclate in the drinking water (2 mg/mL) and the diet 14 days after injection of cancer cells. For drug treatment experiments, mice are intraperitoneally injected with Carboplatin (5 mg/kg per 5 days), Tonabersat (MedChem Express) (10 mg/kg per day), or meclofenamic acid sodium salt (20 mg/kg per day). Vehicle (10% DMSO in polyethylene glycol 400) is used in control mice. Quantification of tumour burden is by Bio-luminescent imaging (BLI), performed using an IVIS Spectrum Xenogen instrument and analysed using Living Image software v.2.50.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.


    Purity: 99.68%

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    TonabersatSB-220453SB220453SB 220453Gap Junction ProteinInhibitorinhibitorinhibit

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