2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. Arginase Aldehyde Dehydrogenase (ALDH) Indoleamine 2,3-Dioxygenase (IDO)
  4. Lacto-N-fucopentaose III

Lacto-N-fucopentaose III  (Synonyms: LNFP-III)

Cat. No.: HY-N11451
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Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.

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Lacto-N-fucopentaose III Chemical Structure

Lacto-N-fucopentaose III Chemical Structure

CAS No. : 25541-09-7

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Based on 1 publication(s) in Google Scholar

Lacto-N-fucopentaose III Related Antibodies

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Description

Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].

In Vitro

Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) induces the production of nitric oxide in inflammatory monocytes. Lacto-N-fucopentaose III reduces migration of dendritic cells across brain endothelium[1].
Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) significantly increased mRNA expression of arginase I (Arg1), aldehyde dehydrogenase 1, subfamily A2 (Aldh1a2), indoleamine 2,3-dioxygenase 1 (Ido1), and heme oxygenase 1 (Homx1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lacto-N-fucopentaose III Related Antibodies
In Vivo

Lacto-N-fucopentaose III glycan (50 μg/mouse; i.v.; twice a week for 2 weeks) significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation, and skews peripheral immune response to a Th2 dominant profile in mice[1].
Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

853.77

Formula

C32H55NO25
CAS No.
SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@H]1O[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@@H]3O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)CO)[C@@H]2O[C@H]4[C@H]([C@@H]([C@@H]([C@@H](O4)C)O)O)O
Structure Classification
Initial Source

schistosomula
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lacto-N-fucopentaose III Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lacto-N-fucopentaose III25541-09-7LNFP-IIIArginaseAldehyde Dehydrogenase (ALDH)Indoleamine 2,3-Dioxygenase (IDO)nitric oxideinflammatory monocytesArg1Aldh1a2Ido1Homx1Inhibitorinhibitorinhibit

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