Lacto-N-fucopentaose III
Based on 1 Customer Validation
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.
For research use only. We do not sell to patients.
- Purity: 96.54%
- CAS No.: 25541-09-7
- Formula: C32H55NO25
- Molecular Weight:853.77
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-W088070A
Agarose,Low melting point
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HY-B2123
Lactose
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HY-N10521
6'-Sialyllactose
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HY-N10528
3-Fucosyllactose
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HY-N2024A
Maltose monohydrate
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HY-W087904
α-Lactose hydrate
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HY-N7575
Lacto-N-fucopentaose II
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HY-B2123R
Lactose (Standard)
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HY-N2024AR
Maltose monohydrate (Standard)
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HY-N10535
Lewis y tetrasaccharide
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HY-W087904R
α-Lactose hydrate (Standard)
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HY-W008864
Lactose octaacetate
Biological Activity
Lacto-N-fucopentaose III glycan (LNFP-III; 50 μg/mL; 48 h) induces the production of nitric oxide in inflammatory monocytes. Lacto-N-fucopentaose III reduces migration of dendritic cells across brain endothelium[1].
Lacto-N-fucopentaose III glycan (50 μg/mL; 48 h) significantly increased mRNA expression of arginase I (Arg1), aldehyde dehydrogenase 1, subfamily A2 (Aldh1a2), indoleamine 2,3-dioxygenase 1 (Ido1), and heme oxygenase 1 (Homx1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lacto-N-fucopentaose III (35 μg dextran conjugate/mouse; s.c.; daily for 2 weeks) ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25541-09-7
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Appearance Solid
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Molecular Weight 853.77
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Formula C32H55NO25
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Color White to off-white
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SMILES
OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@H]1O[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@@H]3O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)CO)[C@@H]2O[C@H]4[C@H]([C@@H]([C@@H]([C@@H](O4)C)O)O)O
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Synonyms
LNFP-III
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Structure Classification
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Initial Source
schistosomula
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhu B, et al. Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis. Clin Immunol. 2012 Mar;142(3):351-61. [Content Brief]
[2]. Brown KA, et al. Lacto-N-fucopentaose-III ameliorates acute and persisting hippocampal synaptic plasticity and transmission deficits in a Gulf War Illness mouse model. Life Sci. 2021 Aug 15;279:119707. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lacto-N-fucopentaose III Related Classifications
HY-N11451 Related Classifications
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