1. Protein Tyrosine Kinase/RTK
  2. FAK
  3. Lewis y tetrasaccharide

Lewis y tetrasaccharide (Synonyms: Lewis y)

Cat. No.: HY-N10535
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Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis.

For research use only. We do not sell to patients.

Lewis y tetrasaccharide Chemical Structure

Lewis y tetrasaccharide Chemical Structure

CAS No. : 82993-43-9

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Description

Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].

In Vitro

Lewis Y tetrasaccharide activates FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression to enhance cell adhesion mediated drug resistance (CAM-DR) in ovarian cancer cells[1].
Lewis Y tetrasaccharide results in integrin α5β1 level increase in ovarian carcinoma-derived cells exhibiting enhanced expression of LeY (RMG-1-hFUT)[2].
Lewis Y tetrasaccharide enhances the adhesive and spreading potentials mediated by the integrin-fibronectin interaction of ovarian carcinoma RMG-1 cells[2].
Anti-LeY antibodies (10 μg/mL; 37 ℃; 24 h) significantly inhibits the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

675.63

Formula

C26H45NO19

CAS No.
SMILES
Structure Classification
Source

human

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Lewis y tetrasaccharide
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