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Lewis X trisaccharide  (Synonyms: Lewis X)

Cat. No.: HY-N10534 Purity: ≥99.0%
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Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis.

For research use only. We do not sell to patients.

Lewis X trisaccharide Chemical Structure

Lewis X trisaccharide Chemical Structure

CAS No. : 71208-06-5

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Lewis X trisaccharide Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Lewis X trisaccharide (Lewis X, Lex) is a potent TH2 regulator, antagonizes LPS-induced IL-12 immune expression. Lewis X trisaccharide is a human histo-blood group antigen, plays an key role in cell-cell adhesion, and servers as a tumor marker. Lewis X trisaccharide is highly expressed in the outer membrane of the parasite, can be used for the immunology research of schistosomiasis[1][2][3].

IC50 & Target

Schistosome

 

In Vitro

Lewis X trisaccharide-BSA (25 μg/mL; 30 min; before LPS stimulation of 10 ng/mL for 4 h) IL-12p40 and suppresses IL-12p70 protein expression induced by Lipopolysaccharide (LPS, HY-D1056)[1].
Lewis X trisaccharide (2 μM; 30 min; before LPS stimulation of 10 ng/mL for 2 h) decreases nuclear NF-κB concentration in mice bone marrow derived dendritic cells (BDDCs)[1].
Lewis X trisaccharide-BSA (25 μg/mL; 48 h) or Lewis X trisaccharide (5 μg/mL; 48 h) plus ovalbumin (OVA, 25 μg/mL) increases cytokines (IL-4, IL-13, and INF-γ) level in mice splenocytes[1].
Lewis X trisaccharide-containing glycoconjugates stimulates B cells to proliferate and to produce factors that down-regulates the TH1 immune response and up-regulates the TH2 immune response[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lewis X trisaccharide Related Antibodies
In Vivo

Lewis X trisaccharide ( 5 μg, combinded with 50 μg ovalbumin; s.c.; once a week for 2 weeks) regulates IgE/TH2 responses, and selectively increases the IgE and IgG1 responses in C3H mice, independent of the LPS-TLR4 signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (BALB/c, IL-12 deficient on a BALB/c background, TLR4-defective C3H/hej, or TLR4-wild type C3H/HeOuj mice) (6-8 weeks old)[1]
Dosage: 5 μg, combinded with 50 μg ovalbumin
Administration: Subcutaneous injection; once a week for 2 weeks
Result: In C3H mice, coupled with BSA (LeX-BSA) and elicited higher levels of specific IgE and IgG1, but not IgG2a, which were associated with increased levels of splenic TH2 cytokines when compared with those seen in BSA-sensitized mice.
In BALB/c mice, induced by ovalbumin, significantly increased levels of specific IgE, resulted IgG2a antibodies concomitant with reduced levels of serum IL-12p70.
In IL-12-deficient BALB/c mice, attenuated the downward trend of the above indicators.
Molecular Weight

529.49

Formula

C20H35NO15
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@H]1O[C@H]([C@H](O)CO)[C@@H]([C@H](C=O)NC(C)=O)O[C@H]2[C@H]([C@@H]([C@@H]([C@@H](O2)C)O)O)O
Structure Classification
Initial Source

human
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Lewis X trisaccharide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lewis X trisaccharide71208-06-5Lewis XParasitegangliosideSialyl-Lewis-X tetrasaccharideSLexcell-cell adhesiontumor markerimmunology researchschistosomiasisparasitic diseaseP-selectindendritic cellsC-type lectin receptorInhibitorinhibitorinhibit

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